Oxidative Stress and Air Pollution Exposure
TLDR
As vehicular traffic is known to importantly contribute to PM exposure, its intensity and quality must be strongly relevant determinants of the qualitative characteristics of PM spread in the atmosphere.Abstract:
Air pollution is associated with increased cardiovascular and pulmonary morbidity and mortality. The mechanisms of air pollution-induced health effects involve oxidative stress and inflammation. As a matter of fact, particulate matter (PM), especially fine (PM2.5, PM < 2.5 μm) and ultrafine (PM0.1, PM < 0.1 μm) particles, ozone, nitrogen oxides, and transition metals, are potent oxidants or able to generate reactive oxygen species (ROS). Oxidative stress can trigger redox-sensitive pathways that lead to different biological processes such as inflammation and cell death. However, it does appear that the susceptibility of target organ to oxidative injury also depends upon its ability to upregulate protective scavenging systems. As vehicular traffic is known to importantly contribute to PM exposure, its intensity and quality must be strongly relevant determinants of the qualitative characteristics of PM spread in the atmosphere. Change in the composition of this PM is likely to modify its health impact.read more
Citations
More filters
Journal ArticleDOI
Particulate matter, air quality and climate: Lessons learned and future needs
Sandro Fuzzi,Urs Baltensperger,Kenneth S. Carslaw,Stefano Decesari,H.A.C. Denier van der Gon,Maria Cristina Facchini,David Fowler,Ilan Koren,Ben Langford,Ulrike Lohmann,Eiko Nemitz,Spyros N. Pandis,Ilona Riipinen,Yinon Rudich,Martijn Schaap,Jay G. Slowik,Dominick V. Spracklen,Elisabetta Vignati,Martin Wild,Martin L. Williams,Stefania Gilardoni +20 more
TL;DR: The literature on atmospheric particulate maffer (PM), or atmospheric aerosol, has increased enormously over the last 2 decades and amounts now to some 1500-2000 papers per year in the refereed literature.
Journal ArticleDOI
Respiratory health effects of diesel particulate matter.
Zoran Ristovski,Branka Miljevic,Nicholas C. Surawski,Lidia Morawska,Kwun M. Fong,Felicia Goh,Ian A. Yang +6 more
TL;DR: This review shows that the DPM surface area and adsorbed organic compounds play a significant role in manifesting chemical and cellular processes that if sustained can lead to the development of adverse respiratory health effects.
Journal ArticleDOI
Neurotoxicity of traffic-related air pollution
TL;DR: Exposure to air pollution, and to traffic‐related air pollution or DE in particular, may lead to neurotoxicity, and air pollution is emerging as a possible etiological factor in neurodevelopmental and neurodegenerative disorders.
Journal ArticleDOI
Polystyrene microplastic particles: In vitro pulmonary toxicity assessment
TL;DR: Findings indicate that PS-MP inhalation may influence human respiratory health, and decreased α1-antitrypsin levels in BEAS-2B cells suggest that exposure to PS- MPs increases the risk for chronic obstructive pulmonary disease, and high concentrations ofPS-MPs can induce these adverse responses.
Journal ArticleDOI
Prenatal Particulate Air Pollution and Asthma Onset in Urban Children. Identifying Sensitive Windows and Sex Differences
Hsiao-Hsien Leon Hsu,Yueh-Hsiu Mathilda Chiu,Brent A. Coull,Itai Kloog,Joel Schwartz,Alison Lee,Robert O. Wright,Rosalind J. Wright +7 more
TL;DR: Higher prenatal PM2.5 exposure at midgestation was associated with asthma development by age 6 years in boys, and distributed lag models adjusting for child age, sex, and maternal factors showed that increased exposure levels at 16-25 weeks gestation were significantly associated with early childhood asthma development.
References
More filters
Journal ArticleDOI
An Association between Air Pollution and Mortality in Six U.S. Cities
Douglas W. Dockery,C A Pope rd,X Xu,John D. Spengler,James H. Ware,Martha E. Fay,Benjamin G. Ferris,Frank E. Speizer +7 more
TL;DR: It is suggested that fine-particulate air pollution, or a more complex pollution mixture associated with fine particulate matter, contributes to excess mortality in certain U.S. cities.
Journal ArticleDOI
Air pollution and health.
TL;DR: The evidence for adverse effects on health of selected air pollutants is discussed, and it is unclear whether a threshold concentration exists for particulate matter and ozone below which no effect on health is likely.
Journal ArticleDOI
Ultrafine particulate pollutants induce oxidative stress and mitochondrial damage.
Ning Li,Constantinos Sioutas,Arthur K. Cho,Debra A. Schmitz,Chandan Misra,Joan M. Sempf,Meiying Wang,Terry D. Oberley,John R. Froines,Andre E. Nel +9 more
TL;DR: The studies demonstrate that the increased biological potency of UFPs is related to the content of redox cycling organic chemicals and their ability to damage mitochondria.
Journal ArticleDOI
Atmospheric aerosols: composition, transformation, climate and health effects.
TL;DR: The current state of knowledge, major open questions, and research perspectives on the properties and interactions of atmospheric aerosols and their effects on climate and human health are outlined.
Journal ArticleDOI
Air quality guidelines for Europe
TL;DR: One of the books you can enjoy now is air quality guidelines for europe who regional publications here.
Related Papers (5)
Estimates and 25-year trends of the global burden of disease attributable to ambient air pollution: an analysis of data from the Global Burden of Diseases Study 2015
Aaron Cohen,Michael Brauer,Richard T. Burnett,H. Ross Anderson,Joseph Frostad,Kara Estep,Kalpana Balakrishnan,Bert Brunekreef,Lalit Dandona,Lalit Dandona,Rakhi Dandona,Valery L. Feigin,Greg Freedman,Bryan Hubbell,Amelia Jobling,Haidong Kan,Luke D. Knibbs,Yang Liu,Randall V. Martin,Lidia Morawska,C. Arden Pope,Hwashin Shin,Kurt Straif,Gavin Shaddick,Matthew L. Thomas,Rita Van Dingenen,Aaron van Donkelaar,Theo Vos,Christopher J L Murray,Mohammad H. Forouzanfar +29 more