Potential role of probiotics on colorectal cancer prevention
Mario Uccello,Giulia Malaguarnera,Francesco Basile,Velia D'Agata,Michele Malaguarnera,Gaetano Bertino,Marco Vacante,Filippo Drago,Antonio Biondi +8 more
TLDR
Several mechanisms could explain the preventive action of probiotics against colorectal cancer onset: alteration of the intestinal microflora; inactivation of cancerogenic compounds; competition with putrefactive and pathogenic microbiota; improvement of the host’s immune response; and inhibition of tyrosine kinase signaling pathways.Abstract:
Background: Colorectal cancer represents the most common malignancy of the gastrointestinal tract. Owing to differences in dietary habits and lifestyle, this neoplasm is more common in industrialized countries than in developing ones. Evidence from a wide range of sources supports the assumption that the link between diet and colorectal cancer may be due to an imbalance of the intestinal microflora. Discussion: Probiotic bacteria are live microorganisms that, when administered in adequate amounts, confer a healthy benefit on the host, and they have been investigated for their protective anti-tumor effects. In vivo and molecular studies have displayed encouraging findings that support a role of probiotics in colorectal cancer prevention. Summary: Several mechanisms could explain the preventive action of probiotics against colorectal cancer onset. They include: alteration of the intestinal microflora; inactivation of cancerogenic compounds; competition with putrefactive and pathogenic microbiota; improvement of the host’s immune response; anti-proliferative effects via regulation of apoptosis and cell differentiation; fermentation of undigested food; inhibition of tyrosine kinase signaling pathways.read more
Citations
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Journal ArticleDOI
Discovering probiotic microorganisms: in vitro, in vivo, genetic and omics approaches.
Konstantinos Papadimitriou,Georgia Zoumpopoulou,Benoît Foligné,Voula Alexandraki,Maria Kazou,Bruno Pot,Effie Tsakalidou +6 more
TL;DR: An overview of the most common assays employed in screening for probiotics is presented, highlighting the potential strengths and limitations of these approaches and how the advent of omics technologies has reshaped the understanding of the biology of probiotics, allowing the exploration of novel routes for screening and studying such microorganisms.
Journal ArticleDOI
Emerging roles of lactic acid bacteria in protection against colorectal cancer.
TL;DR: Recent insights into cellular and molecular mechanisms of LAB in CRC prevention including apoptosis, antioxidant DNA damages, immune responses, immune responding, and epigenetics are discussed.
Journal ArticleDOI
Lactobacillus casei Exerts Anti-Proliferative Effects Accompanied by Apoptotic Cell Death and Up-Regulation of TRAIL in Colon Carcinoma Cells.
Angeliki Tiptiri-Kourpeti,Katerina Spyridopoulou,Valentina Santarmaki,Georgios Aindelis,Evgenia Tompoulidou,Eleftheria Lamprianidou,Georgia Saxami,Petros Ypsilantis,Evangeli Lampri,Constantinos Simopoulos,Ioannis Kotsianidis,Alex Galanis,Yiannis Kourkoutas,Dimitra Dimitrellou,Katerina Chlichlia +14 more
TL;DR: Evidence is provided for beneficial tumor-inhibitory, anti-proliferative and pro-apoptotic effects driven by this probiotic LAB strain against experimental colon cancer.
Journal ArticleDOI
Probiotics, prebiotics and colorectal cancer prevention
TL;DR: Modulation of gut microbiota by probiotics and prebiotics, either alone or in combination could positively influence the cross-talk between immune system and microbiota, would be beneficial in preventing inflammation and CRC.
Journal ArticleDOI
Mediterranean diet and health: food effects on gut microbiota and disease control.
TL;DR: Data integration of food metabotypes and gut microbiota “enterotypes” may allow one to interpret MD adherence and its effects on health in a new way, employable for the design of targeted diets and nutraceutical interventions in childcare and clinical management of food-related diseases, whose onset has been significantly shifted early in life.
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