Potential role of probiotics on colorectal cancer prevention
Mario Uccello,Giulia Malaguarnera,Francesco Basile,Velia D'Agata,Michele Malaguarnera,Gaetano Bertino,Marco Vacante,Filippo Drago,Antonio Biondi +8 more
TLDR
Several mechanisms could explain the preventive action of probiotics against colorectal cancer onset: alteration of the intestinal microflora; inactivation of cancerogenic compounds; competition with putrefactive and pathogenic microbiota; improvement of the host’s immune response; and inhibition of tyrosine kinase signaling pathways.Abstract:
Background: Colorectal cancer represents the most common malignancy of the gastrointestinal tract. Owing to differences in dietary habits and lifestyle, this neoplasm is more common in industrialized countries than in developing ones. Evidence from a wide range of sources supports the assumption that the link between diet and colorectal cancer may be due to an imbalance of the intestinal microflora. Discussion: Probiotic bacteria are live microorganisms that, when administered in adequate amounts, confer a healthy benefit on the host, and they have been investigated for their protective anti-tumor effects. In vivo and molecular studies have displayed encouraging findings that support a role of probiotics in colorectal cancer prevention. Summary: Several mechanisms could explain the preventive action of probiotics against colorectal cancer onset. They include: alteration of the intestinal microflora; inactivation of cancerogenic compounds; competition with putrefactive and pathogenic microbiota; improvement of the host’s immune response; anti-proliferative effects via regulation of apoptosis and cell differentiation; fermentation of undigested food; inhibition of tyrosine kinase signaling pathways.read more
Citations
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Book ChapterDOI
Possibility of Probiotic in Colorectal Cancer: A Specific Countenance to Research
TL;DR: In this paper, the authors highlight huge scientific importance of probiotics as bio-therapeutics in cure and early prevention from colorectal cancer, with recent findings on anticancer effects, in vitro cell line and in vivo animal studies.
Book ChapterDOI
Probiotics as Next Generation Strategy for Cancer Therapy
TL;DR: Probiotics are the substances used for improving health status by improving the fitness of the intestine and overall host health as discussed by the authors, which can maintain sustainable physicochemical conditions by reducing the number of harmful bacteria and in turn decreasing the level of enzymes like glucuronidase and nitroreductase.
Journal ArticleDOI
The effect of neonatal nursing care on clinical symptoms and intestinal flora of children with acute diarrhea.
TL;DR: The association between the gut microbiome and neonatal nursing care at the NICU and the cellular and molecular factors affecting the intestinal flora of children with acute diarrhea are described.
Journal ArticleDOI
آنالیز مولکولی هفت سویه لاکتوباسیلوس جداشده با منشأ انسانی در غرب مازندران به منظور شناسایی جدایههایی با توانایی پروبیوتیکی
Book ChapterDOI
Potential Correlation Between Homeostasis Control and Tumor Microenvironment Regulation of Probiotic as a Therapeutic Agent to Manage Gastrointestinal Cancer
Nabendu Debnath,Ashok Yadav +1 more
TL;DR: Probiotics are mono or mixed cultures of live organisms that confer beneficial health effects to the host upon ingestion in adequate amounts The readily available probiotic preparations present in the market are mainly based on lactic acid bacteria Probiotics show anticarcinogenic effects by reducing activities of microbial enzymes, inducing several cytokines which ameliorate or prevent tumorigenesis through modulation of the host's cellular immune responses, binding potential to carcinogen, producing antitumorigenic or antimutagenic compounds in the colon, altering physiologic conditions (such as pH) in colon,
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