Psychological Stress and the Cutaneous Immune Response: Roles of the HPA Axis and the Sympathetic Nervous System in Atopic Dermatitis and Psoriasis.
Jessica M.F. Hall,desAnges Cruser,Alan Podawiltz,Diana I. Mummert,Harlan P. Jones,Mark E. Mummert,Mark E. Mummert +6 more
TLDR
Understanding how the activity of the psyche-nervous -immune system axis impinges on skin diseases may facilitate coordinated treatment strategies between dermatologists and psychiatrists is highlighted.Abstract:
Psychological stress, an evolutionary adaptation to the fight-or-flight response, triggers a number of physiological responses that can be deleterious under some circumstances. Stress signals activate the hypothalamus-pituitary-adrenal (HPA) axis and the sympathetic nervous system. Elements derived from those systems (e.g., cortisol, catecholamines and neuropeptides) can impact the immune system and possible disease states. Skin provides a first line of defense against many environmental insults. A number of investigations have indicated that the skin is especially sensitive to psychological stress, and experimental evidence shows that the cutaneous innate and adaptive immune systems are affected by stressors. For example, psychological stress has been shown to reduce recovery time of the stratum corneum barrier after its removal (innate immunity) and alters antigen presentation by epidermal Langerhans cells (adaptive immunity). Moreover, psychological stress may trigger or exacerbate immune mediated dermatological disorders. Understanding how the activity of the psyche-nervous -immune system axis impinges on skin diseases may facilitate coordinated treatment strategies between dermatologists and psychiatrists. Herein, we will review the roles of the HPA axis and the sympathetic nervous system on the cutaneous immune response. We will selectively highlight how the interplay between psychological stress and the immune system affects atopic dermatitis and psoriasis.read more
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References
More filters
Journal ArticleDOI
Hypothalamic-pituitary-adrenal axis, neuroendocrine factors and stress.
TL;DR: CRH antagonists may be useful in human pathologic states, such as melancholic depression and chronic anxiety, associated with chronic hyperactivity of the stress system, along with predictable behavioral, neuroendocrine, metabolic and immune changes, based on the interrelations outlined above.
Journal ArticleDOI
Site-restricted persistent cytomegalovirus infection after selective long-term depletion of CD4+ T lymphocytes.
TL;DR: The CD8+ effector cells raised in the CD4 subset- deficient host were able of clear vital tissues from productive infection and to restrict asymptomatic, persistent infection to acinar glandular epithelial cells in salivary gland tissue.
Journal Article
The Sympathetic Nerve—An Integrative Interface between Two Supersystems: The Brain and the Immune System
TL;DR: The activation of SNS during an immune response might be aimed to localize the inflammatory response, through induction of neutrophil accumulation and stimulation of more specific humoral immune responses, although systemically it may suppress Th1 responses, and, thus protect the organism from the detrimental effects of proinflammatory cytokines and other products of activated macrophages.
Journal ArticleDOI
Acute stress enhances while chronic stress suppresses cell-mediated immunity in vivo : a potential role for leukocyte trafficking
TL;DR: The results suggest that stress-induced alterations in lymphocyte redeployment may play an important role in mediating the bi-directional effects of acute versus chronic stress on cell-mediated immunity in vivo.
Journal ArticleDOI
Depressed lymphocyte function after bereavement.
R.W. Bartrop,R.W. Bartrop,L. Lazarus,L. Lazarus,E. Luckhurst,E. Luckhurst,L.G. Kiloh,L.G. Kiloh,Ronald Penny,Ronald Penny +9 more
TL;DR: This is the first time severe psychological stress has been shown to produce a measurable abnormality in immune function which is not obviously caused by hormonal changes.