Role of Matrix Metalloproteinases in Angiogenesis and Cancer.
Saray Quintero-Fabián,Rodrigo Arreola,Enrique Becerril-Villanueva,Julio César Torres-Romero,Victor Arana-Argáez,Julio Lara-Riegos,Mario Alberto Ramírez-Camacho,María Elizbeth Alvarez-Sánchez +7 more
TLDR
This review analyzes recent knowledge on MMPs and their participation in angiogenesis through the modulation of the balance between pro- and anti-angiogenic factors and concludes that Matrix metalloproteinases participate in the disruption, tumor neovascularization, and subsequent metastasis.Abstract:
During angiogenesis, new vessels emerge from existing endothelial lined vessels to promote the degradation of the vascular basement membrane and remodel the extracellular matrix (ECM), followed by endothelial cell migration, and proliferation and the new generation of matrix components. Matrix metalloproteinases (MMPs) participate in the disruption, tumor neovascularization, and subsequent metastasis while tissue inhibitors of metalloproteinases (TIMPs) downregulate the activity of these MMPs. Then, the angiogenic response can be directly or indirectly mediated by MMPs through the modulation of the balance between pro- and anti-angiogenic factors. This review analyzes recent knowledge on MMPs and their participation in angiogenesis.read more
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Recent aspects of the effects of zinc on human health.
Christos T. Chasapis,Christos T. Chasapis,Panagoula-Stamatina A. Ntoupa,Chara Spiliopoulou,Maria Stefanidou +4 more
TL;DR: This review gives a thorough insight into the most recent evidence on the association between Zn biochemistry and human pathologies, epigenetic processes, gut microbial composition, drug targets and nanomedicine.
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The principles of directed cell migration.
TL;DR: In this article, the authors propose four common principles, or pillars, that underlie all forms of directed migration, including signal generation, sensing, and adaptation to asymmetric force relative to the substrate.
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The Role of Macrophages in Cancer Development and Therapy.
TL;DR: In this paper, the role of TAMs in tumor development, including such aspects as protumorigenic inflammation, immune suppression, neoangiogenesis, and enhancement of tissue invasion and distant metastasis.
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TGF-β-mediated exosomal lnc-MMP2-2 regulates migration and invasion of lung cancer cells to the vasculature by promoting MMP2 expression
TL;DR: Results suggested that exosomal lnc‐MMP2‐2 might regulate the migration and invasion of lung cancer cells into the vasculature by promoting MMP2 expression, suggesting this lncRNA as a novel therapeutic target and predictive marker of tumor metastasis in lung cancer.
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Targeting tumor‑associated macrophages in the tumor microenvironment (Review)
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