Journal ArticleDOI
The cardiorespiratory and anesthetic effects of clinical and supraclinical doses of alfaxalone in cats.
TLDR
Alfaxalone produced dose-dependent anesthesia, cardiorespiratory depression and unresponsiveness to noxious stimulation in unpremedicated cats.About:
This article is published in Veterinary Anaesthesia and Analgesia.The article was published on 2008-11-01. It has received 226 citations till now. The article focuses on the topics: Alfaxalone & Respiratory minute volume.read more
Citations
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Journal ArticleDOI
Revisiting the roles of progesterone and allopregnanolone in the nervous system: Resurgence of the progesterone receptors
Michael Schumacher,Claudia Mattern,Abdel M. Ghoumari,Jean-Paul Oudinet,Philippe Liere,Florencia Labombarda,Regine Sitruk-Ware,A. F. De Nicola,Rachida Guennoun +8 more
TL;DR: Effects of progesterone on the nervous system via PR, and of allopregnanolone via its modulation of GABA(A) receptors, are critically discussed, with main focus on the brain.
Journal ArticleDOI
The pharmacokinetics and pharmacodynamics of alfaxalone in cats after single and multiple intravenous administration of Alfaxan® at clinical and supraclinical doses
TL;DR: The pharmacokinetic parameters and pharmacodynamics of alfaxalone in cats after single administration at clinical and supraclinical dose rates and as multiple maintenance doses are determined and it is concluded that Alfaxalone has nonlinear pharmacokinetics in the cat.
Journal ArticleDOI
Comparison of alfaxalone and propofol administered as total intravenous anaesthesia for ovariohysterectomy in dogs
TL;DR: Following premedication with acepromazine and morphine, both propofol and alphaxalone produce good quality anaesthesia adequate for ovariohysterectomy in dogs, suggesting a need for ventilatory support during prolonged infusion periods with either anaesthetic agent.
Journal ArticleDOI
A review of the pharmacology and clinical application of alfaxalone in cats
TL;DR: Based on the published literature, alfaxalone-HPCD provides a good alternative to the existing intravenous anaesthetic options for healthy cats.
Journal ArticleDOI
Induction of anaesthesia with alfaxalone or propofol before isoflurane maintenance in cats
TL;DR: The induction of anaesthesia, the cardiorespiratory variables and the recovery were clinically acceptable and similar after induction with either alfaxalone or propofol.
References
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Molecular and cellular mechanisms of general anaesthesia
TL;DR: It is now clear that anaesthetics act directly on proteins rather than on lipids, with potentiation of postsynaptic inhibitory channel activity best fitting the pharmacological profile observed in general anaesthesia.
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General anesthetic actions in vivo strongly attenuated by a point mutation in the GABA(A) receptor beta3 subunit.
Rachel Jurd,Margarete Arras,Sachar Lambert,Berthold Drexler,Roberta Siegwart,Florence Crestani,Michael Zaugg,Kaspar E. Vogt,Birgit Ledermann,Bernd Antkowiak,Uwe Rudolph +10 more
TL;DR: It is demonstrated that a single molecular target, and indeed a specific residue (N265) located within the GABAA receptor β3 subunit, is a major determinant of behavioral responses evoked by the intravenous anesthetics etomidate and propofol, whereas volatile anesthetic appear to act via a broader spectrum of molecular targets.
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Neurosteroid modulation of GABAA receptors.
TL;DR: Emerging evidence is reviewed that the GABA-modulatory actions of the pregnane steroids are highly selective, with their actions being brain region and indeed neuron dependent, and the sensitivity of GABA(A) receptors is not static but can dynamically change.
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Anesthetic Effect of Steroid Hormones.
TL;DR: Partially hepatectomized rats are much more sensitive to the anesthetic effect of the steroids than intact controls, which probably indicates that the liver plays an important rôle in the detoxification of these compounds.
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The pharmacological properties in animals of ct1341—a new steroid anaesthetic agent
TL;DR: Glaxo CT1341 is a new steroid anaesthetic that produces immediate induction of anaesthesia of short duration when injected intravenously into experimental animals and recovery is rapid and uncomplicated.