The Role of Neural Plasticity in Depression: From Hippocampus to Prefrontal Cortex.
TLDR
The recent literature is summarized to elaborate the possible mechanistic role of neural plasticity in depression and find findings that may pave the way for future progress in neural Plasticity studies.Abstract:
Neural plasticity, a fundamental mechanism of neuronal adaptation, is disrupted in depression. The changes in neural plasticity induced by stress and other negative stimuli play a significant role in the onset and development of depression. Antidepressant treatments have also been found to exert their antidepressant effects through regulatory effects on neural plasticity. However, the detailed mechanisms of neural plasticity in depression still remain unclear. Therefore, in this review, we summarize the recent literature to elaborate the possible mechanistic role of neural plasticity in depression. Taken together, these findings may pave the way for future progress in neural plasticity studies.read more
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Aerobic exercise, cardiorespiratory fitness, and the human hippocampus.
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TL;DR: A review of the physical activity and exercise literature as it pertains to the structure and function of the human hippocampus, focusing on four magnetic resonance imaging measures: volume, diffusion tensor imaging, resting-state functional connectivity, and perfusion, is presented in this paper.
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The novel methoxetamine analogs N-ethylnorketamine hydrochloride (NENK), 2-MeO-N-ethylketamine hydrochloride (2-MeO-NEK), and 4-MeO-N-ethylketamine hydrochloride (4-MeO-NEK) elicit rapid antidepressant effects via activation of AMPA and 5-HT2 receptors
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Long-term high-fat diet consumption by mice throughout adulthood induces neurobehavioral alterations and hippocampal neuronal remodeling accompanied by augmented microglial lipid accumulation.
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TL;DR: In this article, the effects of long-term high-fat diet consumption on brain function were investigated in C57BL/6J mice, and the negative influence of chronic HFD consumption on behavioral and hippocampal neuroplasticity was linked to a change in microglial phenotype that is accompanied by a remarkable increase in cellular lipid accumulation.
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