The Role of Neural Plasticity in Depression: From Hippocampus to Prefrontal Cortex.
TLDR
The recent literature is summarized to elaborate the possible mechanistic role of neural plasticity in depression and find findings that may pave the way for future progress in neural Plasticity studies.Abstract:
Neural plasticity, a fundamental mechanism of neuronal adaptation, is disrupted in depression. The changes in neural plasticity induced by stress and other negative stimuli play a significant role in the onset and development of depression. Antidepressant treatments have also been found to exert their antidepressant effects through regulatory effects on neural plasticity. However, the detailed mechanisms of neural plasticity in depression still remain unclear. Therefore, in this review, we summarize the recent literature to elaborate the possible mechanistic role of neural plasticity in depression. Taken together, these findings may pave the way for future progress in neural plasticity studies.read more
Citations
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Illness Progression, Recent Stress, and Morphometry of Hippocampal Subfields and Medial Prefrontal Cortex in Major Depression
Michael T. Treadway,Michael Waskom,Daniel G. Dillon,Avram J. Holmes,Avram J. Holmes,Min Tae M. Park,M. Mallar Chakravarty,M. Mallar Chakravarty,Sunny J. Dutra,Frida E. Polli,Dan V. Iosifescu,Maurizio Fava,John D. E. Gabrieli,Diego A. Pizzagalli +13 more
TL;DR: In this paper, structural magnetic resonance imaging was performed to examine relationships between number of prior depressive episodes, current stress, hippocampal subfield volume and cortical thickness, and they found evidence for morphometric changes that are consistent with stress-sensitization models of recurrence in MDD.
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The Role of BDNF on Neural Plasticity in Depression.
TL;DR: The studies reviewed here may suggest new possible targets for antidepressant drugs such as neurotrophins, their receptors, and relevant signaling pathways, and agents facilitating the activation of gene expression and increasing the transcription of neurotrophic factors in the brain.
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Chronic Pain: Structural and Functional Changes in Brain Structures and Associated Negative Affective States.
Seoyon Yang,Min Cheol Chang +1 more
TL;DR: The results of previous studies are summarized, focusing on the mechanisms underlying chronic pain development and the identification of neural areas related to chronic pain, to provide guidance for the development of future therapeutic approaches that could be used in the management of chronic pain.
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Antidepressants affect gut microbiota and Ruminococcus flavefaciens is able to abolish their effects on depressive-like behavior
TL;DR: It is demonstrated that various types of antidepressants alter gut microbiota composition, and further implicate a role for R. flavefaciens in alleviating depressive-like behavior, and a mechanism for microbial regulation of antidepressant treatment efficiency is suggested.
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Circulating microRNAs as potential biomarkers for psychiatric and neurodegenerative disorders.
M.M.J. van den Berg,Julian Krauskopf,Johannes G. Ramaekers,Jos C. S. Kleinjans,Jos Prickaerts,Jacco J. Briedé +5 more
TL;DR: This review aims to provide a comprehensive assessment on the current progress regarding the potential value of cimiRNAs as central nervous system (CNS) biomarkers and shows that the type of bodily fluid used for measuring cimi RNAs is important as inconsistencies in cimiRNAAs expression directions are found when comparing CSF, blood cell-free andBlood cell-bound samples.
References
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Transcutaneous vagus nerve stimulation modulates amygdala functional connectivity in patients with depression.
Jun Liu,Jiliang Fang,Zengjian Wang,Peijing Rong,Yang Hong,Yangyang Fan,Xiaoling Wang,Joel Park,Yu Jin,Chun-Hong Liu,Bing Zhu,Jian Kong +11 more
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