The Role of Neural Plasticity in Depression: From Hippocampus to Prefrontal Cortex.
TLDR
The recent literature is summarized to elaborate the possible mechanistic role of neural plasticity in depression and find findings that may pave the way for future progress in neural Plasticity studies.Abstract:
Neural plasticity, a fundamental mechanism of neuronal adaptation, is disrupted in depression. The changes in neural plasticity induced by stress and other negative stimuli play a significant role in the onset and development of depression. Antidepressant treatments have also been found to exert their antidepressant effects through regulatory effects on neural plasticity. However, the detailed mechanisms of neural plasticity in depression still remain unclear. Therefore, in this review, we summarize the recent literature to elaborate the possible mechanistic role of neural plasticity in depression. Taken together, these findings may pave the way for future progress in neural plasticity studies.read more
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Antidepressant-like Effects of BDNF and NGF Individual Loop Dipeptide Mimetics Depend on the Signal Transmission Patterns Associated with Trk
A. G. Mezhlumyan,A. V. Tallerova,P. Yu. Povarnina,Aleksey V Tarasiuk,N. M. Sazonova,T. A. Gudasheva,Sergey B. Seredenin +6 more
TL;DR: Comparative research of the antidepressant-like activity of the dimeric dipeptide mimetics of brain-derived neurotrophic factor and BDNF at acute and subchronic administration in the forced swim test in mice demonstrates that the low-molecular weight BDNF mimetic GSB-106 that activates all three main post-receptor TrkB signaling pathways is the most promising for the development as an antidepressant.
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Phencynonate hydrochloride exerts antidepressant effects by regulating the dendritic spine density and altering glutamate receptor expression.
Yingqi Zhu,Yi-shan Qu,Jing Zhang,Jun Hou,Jie Fang,Jingxuan Shen,Chang Xu,Minyi Huang,Hui Qiao,Shu-Cheng An +9 more
TL;DR: Phencynonate hydrochloride (PCH) is a drug that crosses the blood-brain barrier as mentioned in this paper and has been shown to alleviate depression-like behaviors induced by chronic unpredictable mild stress (CUMS).
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Brain structural correlates of recurrence following the first episode in patients with major depressive disorder
Hannah Lemke,Hannah Klute,Jennifer Skupski,Katharina Thiel,Lena Waltemate,Alexandra Winter,Fabian Breuer,Susanne Meinert,Melissa Klug,Verena Enneking,Nils R. Winter,Dominik Grotegerd,Elisabeth J. Leehr,Jonathan Repple,Katharina Dohm,Nils Opel,Frederike Stein,Tina Meller,Katharina Brosch,Kai Ringwald,Juliane Pfarr,Florian Thomas-Odenthal,Tim Hahn,Axel Krug,Andreas Jansen,Walter Heindel,Igor Nenadic,Tilo Kircher,Udo Dannlowski +28 more
TL;DR: In this article , the authors examined changes in brain structure in patients with first-episode depression over 2 years and found evidence for neural alterations in the DLPFC and insula related to a detrimental course in MDD.
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Relationships of Physical Activity, Depression, and Sleep with Cognitive Function in Community-Dwelling Older Adults
Ka-Won Kim,Gyubeom Hwang,Yong Hyuk Cho,Eun Jwoo Kim,Ji Won Woang,Chang Hyung Hong,Sang Joon Son,Hyun Woong Roh +7 more
TL;DR: In this article , a cross-sectional, observational study aimed to integrate the analyses of relationships of physical activity, depression, and sleep with cognitive function in community-dwelling older adults using a single model.
Book ChapterDOI
Impaired mitochondrial bioenergetics in psychiatric disorders
TL;DR: In this paper, the authors focus on the links between mitochondrial energy production, calcium homeostasis, apoptosis and synaptic plasticity, and the above disorders; discussing evidence for the involvement of mitochondrial and mitochondria-related nuclear genes, presenting a critical view about causal inference based on the accumulated evidence.
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