A
Alok Dhawan
Researcher at Indian Institute of Toxicology Research
Publications - 173
Citations - 10570
Alok Dhawan is an academic researcher from Indian Institute of Toxicology Research. The author has contributed to research in topics: Comet assay & Genotoxicity. The author has an hindex of 47, co-authored 170 publications receiving 9435 citations. Previous affiliations of Alok Dhawan include Council of Scientific and Industrial Research & Academy of Scientific and Innovative Research.
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Zinc oxide nanoparticles induce oxidative DNA damage and ROS-triggered mitochondria mediated apoptosis in human liver cells (HepG2)
TL;DR: The results demonstrate that HepG2 cells exposed to 14–20 μg/ml ZnO nanoparticles for 12 h showed a decrease in cell viability and the mode of cell death induced by Zn O nanoparticles was apoptosis, and apoptosis was found to be independent of JNK and p38 pathways.
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DNA damaging potential of zinc oxide nanoparticles in human epidermal cells.
TL;DR: The data demonstrates that ZnO NPs even at low concentrations possess a genotoxic potential in human epidermal cells which may be mediated through lipid peroxidation and oxidative stress, Hence, caution should be taken in their use in dermatological preparations as well as while handling.
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Mechanisms of genotoxicity. A review of in vitro and in vivo studies with engineered nanoparticles.
TL;DR: The need for appropriate methodologies to be used for investigation of genotoxic effects of NPs, in vitro and in vivo is suggested and advantages and potential problems with different methods are described.
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ROS-mediated genotoxicity induced by titanium dioxide nanoparticles in human epidermal cells
TL;DR: It is demonstrated that TiO(2) NPs have a mild cytotoxic potential, however, they induce ROS and oxidative stress leading to oxidative DNA damage and micronucleus formation, a probable mechanism of genotoxicity.
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Toxicity assessment of nanomaterials: methods and challenges
Alok Dhawan,Vyom Sharma +1 more
TL;DR: This review is an attempt to highlight some important methods employed in nanomaterial toxicology and to provide a critical analysis of the major issues/challenges faced in this emerging field.