Z
Zuzana Magdolenova
Researcher at Norwegian Institute for Air Research
Publications - 22
Citations - 1920
Zuzana Magdolenova is an academic researcher from Norwegian Institute for Air Research. The author has contributed to research in topics: Comet assay & Genotoxicity. The author has an hindex of 17, co-authored 22 publications receiving 1626 citations.
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Journal ArticleDOI
Mechanisms of genotoxicity. A review of in vitro and in vivo studies with engineered nanoparticles.
TL;DR: The need for appropriate methodologies to be used for investigation of genotoxic effects of NPs, in vitro and in vivo is suggested and advantages and potential problems with different methods are described.
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Toxicity screenings of nanomaterials: challenges due to interference with assay processes and components of classic in vitro tests.
Rina Guadagnini,Blanka Halamoda Kenzaoui,Laura Walker,Giulio Pojana,Zuzana Magdolenova,Dagmar Bilanicova,Margaret Saunders,Lucienne Juillerat-Jeanneret,Antonio Marcomini,Anna Huk,Maria Dusinska,Lise Marie Fjellsbø,Francelyne Marano,Sonja Boland +13 more
TL;DR: It is shown that many NP characteristics interfere with a range of in vitro cytotoxicity assays, and how to integrate and avoid interference with testing systems is proposed as a first step of a screening strategy for biomedical NPs.
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Interlaboratory comparison of size measurements on nanoparticles using nanoparticle tracking analysis (NTA)
Patrick Hole,Katherine Sillence,Claire Hannell,Ciaran Manus Maguire,Matthias Roesslein,Guillaume Suarez,Sonja Capracotta,Zuzana Magdolenova,Limor Horev-Azaria,Agnieszka Dybowska,Laura Cooke,Andrea Haase,Servane Contal,Stein Manø,Antje Vennemann,Jeans-Jacques Sauvain,Kieran Crosbie Staunton,Sergio Anguissola,Andreas Luch,Maria Dusinska,Rafi Korenstein,Arno C. Gutleb,Martin Wiemann,Adriele Prina-Mello,Michael Riediker,Peter Wick +25 more
TL;DR: This study looks at the reproducibility using a relatively new, but rapidly adopted, technique, Nanoparticle Tracking Analysis (NTA) on a range of particle sizes and materials in several different media and how this leads to highly reproducible results amongst participants.
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Impact of agglomeration and different dispersions of titanium dioxide nanoparticles on the human related in vitro cytotoxicity and genotoxicity
Zuzana Magdolenova,Dagmar Bilanicova,Giulio Pojana,Lise Marie Fjellsbø,Alexandra Hudecova,Katarina Hasplova,Antonio Marcomini,Maria Dusinska +7 more
TL;DR: An increased level of DNA oxidation lesions detected in Cos-1 and TK6 cells indicates that the leading mechanism by which TiO(2) NPs trigger genotoxicity is most likely oxidative stress.
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Can standard genotoxicity tests be applied to nanoparticles
TL;DR: Experiments were conducted to determine the validity of two common genotoxicity testing procedures, the comet assay and the micronucleus test, when applied to nanoparticles (NP), and it was found that incubation of cells with NP before treatment with a known 8-oxoguanine-inducing agent does not lead to any decrease in the yield of FPG-sensitive sites.