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Ann M O'Hara
Researcher at National University of Ireland
Publications - 7
Citations - 2973
Ann M O'Hara is an academic researcher from National University of Ireland. The author has contributed to research in topics: Inflammatory bowel disease & Intestinal mucosa. The author has an hindex of 5, co-authored 7 publications receiving 2636 citations.
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Journal ArticleDOI
The gut flora as a forgotten organ
Ann M O'Hara,Fergus Shanahan +1 more
TL;DR: The flora has a collective metabolic activity equal to a virtual organ within an organ, and the mechanisms underlying the conditioning influence of the bacteria on mucosal homeostasis and immune responses are beginning to be unravelled.
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Functional modulation of human intestinal epithelial cell responses by Bifidobacterium infantis and Lactobacillus salivarius
Ann M O'Hara,Padraig O'Regan,Aine Fanning,Caitlin O'Mahony,John MacSharry,Anne Lyons,John Bienenstock,Liam O'Mahony,Fergus Shanahan +8 more
TL;DR: The data demonstrate that, although the intestinal epithelium is immunologically quiescent when it encounters B.“infantis or L.”salivarius, these commensal bacteria exert immunomodulatory effects on intestinal immune cells that mediate host responses to flagellin and enteric pathogens.
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Gut Microbiota: Mining for Therapeutic Potential
Ann M O'Hara,Fergus Shanahan +1 more
TL;DR: Manipulation of the microbiota to enhance its beneficial components thus represents a potential therapeutic strategy for inflammatory bowel disease and the microbiota might be a rich repository of metabolites that can be exploited for therapeutic benefit.
Journal ArticleDOI
Mechanisms of action of probiotics in intestinal diseases.
Ann M O'Hara,Fergus Shanahan +1 more
TL;DR: Scientally accredited evidence of efficacy and studies to elucidate the molecular mechanisms of host-microbiota interactions are needed to lend credence to the use of pharmabiotic strategies in clinical medicine.
Journal ArticleDOI
Modulation of pathogen-induced CCL20 secretion from HT-29 human intestinal epithelial cells by commensal bacteria
Shomik Sibartie,Ann M O'Hara,Jude Ryan,Aine Fanning,Jim O'Mahony,Shaun O'Neill,B. Sheil,Liam O'Mahony,Fergus Shanahan +8 more
TL;DR: This study is the first to demonstrate that a commensal strain can attenuate CCL20 secretion in HT-29 IECs, indicating that M. paratuberculosis may mediate mucosal damage and that B. infantis can exert immunomodulatory effects on I ECs that mediate host responses to flagellin and flageLLated enteric pathogens.