B
Begonya Comin-Anduix
Researcher at University of California, Los Angeles
Publications - 53
Citations - 4969
Begonya Comin-Anduix is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Melanoma & Immunotherapy. The author has an hindex of 28, co-authored 52 publications receiving 3945 citations. Previous affiliations of Begonya Comin-Anduix include California Institute of Technology & UCLA Medical Center.
Papers
More filters
Journal ArticleDOI
Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression.
Angel Garcia-Diaz,Daniel Sanghoon Shin,Blanca Homet Moreno,Justin Saco,Helena Escuin-Ordinas,Gabriel Abril Rodriguez,Jesse M. Zaretsky,Lu Sun,Willy Hugo,Xiaoyan Wang,Giulia Parisi,Cristina Puig Saus,Davis Y. Torrejon,Thomas G. Graeber,Begonya Comin-Anduix,Siwen Hu-Lieskovan,Robert Damoiseaux,Roger S. Lo,Antoni Ribas +18 more
TL;DR: Analysis of biopsy specimens from patients with melanoma confirmed interferon signature enrichment and upregulation of gene targets for STAT1/STAT2/STAT3 and IRF1 in anti-PD-1-responding tumors.
Journal ArticleDOI
A clinical microchip for evaluation of single immune cells reveals high functional heterogeneity in phenotypically similar T cells
Chao Ma,Rong Fan,Rong Fan,Habib Ahmad,Qihui Shi,Begonya Comin-Anduix,Thinle Chodon,Richard C. Koya,Chao-Chao Liu,Gabriel A. Kwong,Caius G. Radu,Caius G. Radu,Antoni Ribas,Antoni Ribas,James R. Heath +14 more
TL;DR: A microfluidic platform designed for highly multiplexed, reliable, sample-efficient and quantitative measurements of secreted proteins from single cells is reported, which represents a new and informative tool for immune monitoring and clinical assessment.
Journal ArticleDOI
CTLA4 blockade broadens the peripheral T cell receptor repertoire
Lidia Robert,Jennifer Tsoi,Xiaoyan Wang,Ryan O. Emerson,Blanca Homet,Blanca Homet,Thinle Chodon,Stephen Mok,Rong R. Huang,Alistair J. Cochran,Begonya Comin-Anduix,Richard C. Koya,Thomas G. Graeber,Harlan Robins,Antoni Ribas +14 more
TL;DR: There was a significant difference in the total unique productive TCR V-beta CDR3 sequences between patients experiencing toxicity with tremelimumab compared with patients without toxicity, representing a pharmacodynamic effect of how this class of antibodies modulates the human immune system.
Journal ArticleDOI
HMGB1 Mediates Endogenous TLR2 Activation and Brain Tumor Regression
James F. Curtin,James F. Curtin,Naiyou Liu,Naiyou Liu,Marianela Candolfi,Marianela Candolfi,Weidong Xiong,Weidong Xiong,Hikmat Assi,Hikmat Assi,Kader Yagiz,Kader Yagiz,Matthew R. Edwards,Kathrin S. Michelsen,Kurt M. Kroeger,Kurt M. Kroeger,Chunyan Liu,Chunyan Liu,A.K.M. Ghulam Muhammad,A.K.M. Ghulam Muhammad,Mary C. Clark,Mary C. Clark,Moshe Arditi,Begonya Comin-Anduix,Antoni Ribas,Pedro R. Lowenstein,Maria G. Castro +26 more
TL;DR: Evidence is provided for the molecular and cellular mechanisms that support the rationale for the clinical implementation of antibrain cancer immunotherapies in combination with tumor killing approaches in order to elicit effective antitumor immune responses, and thus, will impact clinical neuro-oncology practice.
Journal ArticleDOI
Key Parameters of Tumor Epitope Immunogenicity Revealed Through a Consortium Approach Improve Neoantigen Prediction
Daniel K. Wells,Marit M. van Buuren,Kristen K. Dang,Vanessa M. Hubbard-Lucey,Kathleen C. F. Sheehan,Katie M. Campbell,Andrew Lamb,Jeffrey P. Ward,John Sidney,Ana Belen Blazquez,Andrew J. Rech,Jesse M. Zaretsky,Begonya Comin-Anduix,Alphonsus H. C. Ng,William Chour,Thomas Yu,Hira Rizvi,Jia M. Chen,Patrice Manning,Gabriela Steiner,Xengie Doan,Aly A. Khan,Amit A. Lugade,Ana M. Mijalkovic Lazic,Angela Frentzen,Arbel D. Tadmor,Ariella Sasson,Arjun A. Rao,Baikang Pei,Barbara Schrörs,Beata Berent-Maoz,Beatriz M. Carreno,Bin Song,Bjoern Peters,Bo Li,Brandon W. Higgs,Brian Stevenson,Christian Iseli,Christopher A. Miller,Christopher A. Morehouse,Cornelis J. M. Melief,Cristina Puig-Saus,Daphne van Beek,David Balli,David Gfeller,David Haussler,Dirk Jäger,Eduardo Cortes,Ekaterina Esaulova,Elham Sherafat,Francisco Arcila,Gabor Bartha,Geng Liu,George Coukos,Guilhem Richard,Han Chang,Han Si,Inka Zörnig,Ioannis Xenarios,Ion I. Mandoiu,Irsan Kooi,James P. Conway,Jan H. Kessler,Jason A. Greenbaum,Jason Perera,Jason Harris,Jasreet Hundal,Jennifer M. Shelton,Jianmin Wang,Jiaqian Wang,Joel Greshock,Jonathon Blake,Joseph D. Szustakowski,Julia Kodysh,Juliet Forman,Lei Wei,Leo J. Lee,Lorenzo F. Fanchi,Maarten Slagter,Maren Lang,Markus Mueller,Martin Löwer,Mathias Vormehr,Maxim N. Artyomov,Michael A. Kuziora,Michael F. Princiotta,Michal Bassani-Sternberg,Mignonette H. Macabali,Milica R. Kojicic,Naibo Yang,Nevena M. Ilic Raicevic,Nicolas Guex,Nicolas Robine,Niels Halama,Nikola M. Skundric,Ognjen Milicevic,Pascal Gellert,Patrick Jongeneel,Pornpimol Charoentong,Pramod K. Srivastava,Prateek Tanden,Priyanka Shah,Qiang Hu,Ravi Gupta,Richard Chen,Robert A. Petit,Robert Ziman,Rolf Hilker,Sachet A. Shukla,Sahar Al Seesi,Sean Michael Boyle,Si Qiu,Siranush Sarkizova,Sofie R. Salama,Song Liu,Song Wu,Sriram Sridhar,Steven L. C. Ketelaars,Suchit Jhunjhunwala,Tatiana Shcheglova,Thierry Schuepbach,Todd Creasy,Veliborka Josipovic,Vladimir B. Kovacevic,Weixuan Fu,Willem-Jan Krebber,Yi-Hsiang Hsu,Yinong Sebastian,Zeynep Kosaloglu Yalcin,Zhiqin Huang,Taha Merghoub,Taha Merghoub,Justin Guinney,Justin Guinney,Adam Kolom,Cheryl Selinsky,Antoni Ribas,Antoni Ribas,Matthew D. Hellmann,Nir Hacohen,Nir Hacohen,Alessandro Sette,Alessandro Sette,James R. Heath,Nina Bhardwaj,Fred Ramsdell,Robert D. Schreiber,Ton N. Schumacher,Pia Kvistborg,Nadine Defranoux +149 more
TL;DR: A model of tumor epitope immunogenicity was developed that filtered out 98% of non-immunogenic peptides with a precision above 0.70 and was validated in an independent cohort of 310 epitopes prioritized from tumor sequencing data and assessed for T cell binding.