G
Gabriel Abril Rodriguez
Researcher at University of California
Publications - 6
Citations - 2045
Gabriel Abril Rodriguez is an academic researcher from University of California. The author has contributed to research in topics: Alcohol dehydrogenase & Melanoma. The author has an hindex of 2, co-authored 5 publications receiving 1375 citations. Previous affiliations of Gabriel Abril Rodriguez include University of California, Los Angeles.
Papers
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Journal ArticleDOI
Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression.
Angel Garcia-Diaz,Daniel Sanghoon Shin,Blanca Homet Moreno,Justin Saco,Helena Escuin-Ordinas,Gabriel Abril Rodriguez,Jesse M. Zaretsky,Lu Sun,Willy Hugo,Xiaoyan Wang,Giulia Parisi,Cristina Puig Saus,Davis Y. Torrejon,Thomas G. Graeber,Begonya Comin-Anduix,Siwen Hu-Lieskovan,Robert Damoiseaux,Roger S. Lo,Antoni Ribas +18 more
TL;DR: Analysis of biopsy specimens from patients with melanoma confirmed interferon signature enrichment and upregulation of gene targets for STAT1/STAT2/STAT3 and IRF1 in anti-PD-1-responding tumors.
Journal ArticleDOI
Primary Resistance to PD-1 Blockade Mediated by JAK1/2 Mutations.
Daniel Sanghoon Shin,Jesse M. Zaretsky,Helena Escuin-Ordinas,Angel Garcia-Diaz,Siwen Hu-Lieskovan,Anusha Kalbasi,Catherine S. Grasso,Willy Hugo,Salemiz Sandoval,Davis Y. Torrejon,Nicolaos Palaskas,Gabriel Abril Rodriguez,Giulia Parisi,Ariel M. Azhdam,Bartosz Chmielowski,Grace Cherry,Elizabeth Seja,Beata Berent-Maoz,I. Peter Shintaku,Dung Thi Le,Drew M. Pardoll,Luis A. Diaz,Paul C. Tumeh,Thomas G. Graeber,Roger S. Lo,Begoña Comin-Anduix,Antoni Ribas +26 more
TL;DR: It is proposed that JAK1/2 loss-of-function mutations are a genetic mechanism of lack of reactive PD-L1 expression and response to interferon gamma, leading to primary resistance to PD-1 blockade therapy.
Patent
Escherichia coli engineered for isobutyraldehyde production
TL;DR: The use of 2-keto-acid decarboxylase can be used for producing higher aldehydes or other non-alcohol chemicals derived from aldehyde as mentioned in this paper.
Patent
Bacteria engineered for ester production
TL;DR: In this article, the authors provided a disclosure of recombinant bacteria with 2-keto acid decarboxylase and alcohol transferase activity, and showed that some of the recombinant proteins further have reduced alcohol dehydrogenase and/or aldehyde reductase activity.
Journal ArticleDOI
Abstract 3818: Infrequent chromosomal loss and recurrent gains lead to imbalanced expression of HLA genes in melanoma
Katie M. Campbell,Justin Saco,Egmidio Medina,Meelad Amouzgar,Shannon M. Pfeiffer,C.R. Salinas Gonzalez,Gabriela Steiner,Ameya Champhekar,Cristina Puig Saus,Jesse M. Zaretsky,Gabriel Abril Rodriguez,Agustin Vega-Crespo,Ignacio Baselga Carretero,Mito Tariveranmoshabad,Anusha Kalbasi,Christine Spencer,Zachary L. Skidmore,Malachi Griffith,Obi L. Griffith,Daniel K. Wells,Antoni Ribas +20 more
TL;DR: Evaluation of paired tumor WES and RNAseq revealed orthogonal validation of HLA allelic imbalance, and analysis in cell lines suggested that these patterns were likely tumor intrinsic, suggesting that antigen presentation density can be modulated by chromosomal gains, and not just allelic loss, in HLA genes.