Xiaoyan Wang

TL;DR: Analysis of biopsy specimens from patients with melanoma confirmed interferon signature enrichment and upregulation of gene targets for STAT1/STAT2/STAT3 and IRF1 in anti-PD-1-responding tumors.

TL;DR: In this paper, gene expression analysis of human melanoma cell lines and patient tumors revealed that melanoma follows a two-dimensional differentiation trajectory that can be subclassified into four progressive subtypes associated with subtype-specific sensitivity to iron-dependent oxidative stress and cell death known as ferroptosis.

TL;DR: There was a significant difference in the total unique productive TCR V-beta CDR3 sequences between patients experiencing toxicity with tremelimumab compared with patients without toxicity, representing a pharmacodynamic effect of how this class of antibodies modulates the human immune system.

TL;DR: PD-1 blockade increases the frequency of T cells, B cells, and myeloid-derived suppressor cells in tumors, with the CD8+ effector memory T-cell subset being the major T- cell phenotype expanded in patients with a response to therapy.

TL;DR: ZFN-driven gene correction in CD34(+) cells from the bone marrow of patients with SCD resulted in the production of wild-type hemoglobin tetramers, demonstrating efficient targeted cleavage at the β-globin locus with minimal off-target modification.