Benjamin Rouse

TL;DR: The key assumption of network meta-analysis is discussed, as well as the unique considerations for developing appropriate research questions, conducting the literature search, abstracting data, performing qualitative and quantitative synthesis, presenting results, drawing conclusions, and reporting the findings in a networkMeta-analysis.

TL;DR: In this article, the authors performed a systematic review and network meta-analysis to assess the comparative effectiveness of first-line medical treatments in patients with primary open-angle glaucoma (POAG) or ocular hypertension, and to provide relative rankings of these treatments.

TL;DR: Of the primary outcomes, the only one with evidence of a difference from more than one trial under the pair-wise comparison was in the number of adverse events (complications), which was higher with radiofrequency dissecting sealer than with the clamp-crush method.

TL;DR: The best induction therapy to reduce mortality from HIV‐associated cryptococcal meningitis is unclear, particularly in resource‐limited settings where management of drug‐related toxicities associated with more potent antifungal drugs is a challenge.

TL;DR: The evidence base for first-line medical treatments of POAG is compared with the recommendations for each major revision of the AAO PPP by using cumulative network meta-analysis (that is, conducting a series of networkMeta-analysis on a systematically assembled set of RCTs published up to several distinct periods).