B
Bhawani Aryasomayajula
Researcher at Northeastern University
Publications - 8
Citations - 400
Bhawani Aryasomayajula is an academic researcher from Northeastern University. The author has contributed to research in topics: Efficacy & Head and neck cancer. The author has an hindex of 4, co-authored 8 publications receiving 312 citations.
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Journal ArticleDOI
Barriers to drug delivery in solid tumors
TL;DR: This review hopes to provide the reader with a clear understanding and knowledge of biological barriers and the methods to exploit these characteristics to design multifunctional nanocarriers, effect useful dosing regimens and subsequently improve therapeutic outcomes in the clinic.
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Solid lipid nanoparticles co-loaded with doxorubicin and α-tocopherol succinate are effective against drug-resistant cancer cells in monolayer and 3-D spheroid cancer cell models.
Mariana Silva Oliveira,Bhawani Aryasomayajula,Bhushan S. Pattni,Samuel V. Mussi,Lucas Antônio Miranda Ferreira,Vladmir P. Torchilin +5 more
TL;DR: Solid lipid nanoparticles co-loaded with doxorubicin and TS showed a prominent cytotoxicity and a greater penetration of doxorbicin in cancer cell spheroids and in the monolayer model, suggesting a bypassing of P-glycoprotein bomb efflux.
Journal ArticleDOI
Cancer cell spheroids for screening of chemotherapeutics and drug-delivery systems
Niravkumar R. Patel,Bhawani Aryasomayajula,Abraham H. Abouzeid,Vladimir P. Torchilin,Vladimir P. Torchilin +4 more
TL;DR: In this review, production of cancer cell spheroids, utilization of these sp Heroids in understanding various therapeutic mechanisms and the potential for their use in high-throughput screening of drugs and drug-delivery systems are discussed in detail.
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Erratum to: Targeting of Micelles and Liposomes Loaded with the Pro-Apoptotic Drug, NCL-240, into NCI/ADR-RES Cells in a 3D Spheroid Model.
Bhushan S. Pattni,Srikar G. Nagelli,Bhawani Aryasomayajula,Pranali P. Deshpande,Abhijit R. Kulkarni,William C. Hartner,Ganesh A. Thakur,Alexei Degterev,Vladimir P. Torchilin,Vladimir P. Torchilin +9 more
TL;DR: To develop transferrin (Tf)-targeted delivery systems for the pro-apoptotic drug, NCL-240, and to evaluate the efficacy of this delivery system in ovarian cancer NCI/ADR-RES cells, grown in vitro in a 3D spheroid model.
Journal Article
Safety and efficacy of quadrapeutics versus chemoradiation in head and neck carcinoma xenograft model
Ekaterina Y. Lukianova-Hleb,Yoo Shin Kim,Bhawani Aryasomayajula,Teni Boulikas,Jack Phan,Mien Chie Hung,Vladimir P. Torchilin,Brian E. O'Neill,Dmitri O. Lapotko +8 more
TL;DR: In this paper, the authors compared cell-level combination approach, quadrapeutics, to chemoradiation therapy to establish pre-clinical data for its biodistribution, safety and efficacy in head and neck squamous cell carcinoma (HNSCC), as a clinically challenging aggressive and resistant cancer.