Alexei Degterev

TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: It is demonstrated that necroptosis contributes to delayed mouse ischemic brain injury in vivo through a mechanism distinct from that of apoptosis and offers a new therapeutic target for stroke with an extended window for neuroprotection.

TL;DR: Necroptosis is a cellular mechanism of necrotic cell death induced by apoptotic stimuli in the form of death domain receptor engagement by their respective ligands under conditions where apoptotic execution is prevented and necrostatins are established as the first-in-class inhibitors of RIP1 kinase, the key upstream kinase involved in the activation of necroptosis.

TL;DR: A large number of caspases from the cysteine proteases family play important roles in regulating apoptosis, and the mechanisms by which they mediate apoptosis and a variety of physiological and pathological processes are studied.

TL;DR: A cellular signaling network that regulates necroptosis and the molecular bifurcation that controls apoptosis and ne croptosis is defined and it is shown that the expression of subsets of the 432 genes is enriched in the immune and nervous systems, and cellular sensitivity to necroPTosis is regulated by an extensive signaling network mediating innate immunity.