Barriers to drug delivery in solid tumors
TLDR
This review hopes to provide the reader with a clear understanding and knowledge of biological barriers and the methods to exploit these characteristics to design multifunctional nanocarriers, effect useful dosing regimens and subsequently improve therapeutic outcomes in the clinic.Abstract:
Over the last decade, significant progress has been made in the field of drug delivery. The advent of engineered nanoparticles has allowed us to circumvent the initial limitations to drug delivery ...read more
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To exploit the tumor microenvironment: Since the EPR effect fails in the clinic, what is the future of nanomedicine?
TL;DR: The basic rationale of the design and development of nanomedicines in cancer therapy is failing making it necessary to stop claiming efficacy gains via the EPR effect, while tumor targeting cannot be proved in the clinic, so it is probably time to dethrone the E PR effect.
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Nanodrug Delivery: Is the Enhanced Permeability and Retention Effect Sufficient for Curing Cancer?
TL;DR: Various barriers for nanosized drug delivery are overviewed with an emphasis on the capillary wall's resistance, the main obstacle to delivering drugs.
Journal ArticleDOI
Engineered nanomedicines with enhanced tumor penetration
Jianxun Ding,Jinjin Chen,Liqian Gao,Zhongyu Jiang,Yu Zhang,Mingqiang Li,Qicai Xiao,Su Seong Lee,Xuesi Chen +8 more
TL;DR: The multifunctional transformable nanoparticles have emerged as an advanced generation of nanomedicine with superior tumor penetration capabilities and prospects for improving tumor penetration are discussed.
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Surface Functionalization and Targeting Strategies of Liposomes in Solid Tumor Therapy: A Review.
Muhammad Kashif Riaz,Muhammad Adil Riaz,Xue Zhang,Congcong Lin,Ka Hong Wong,Xiaoyu Chen,Ge Zhang,Aiping Lu,Zhijun Yang +8 more
TL;DR: Information is reviewed about the strategies for targeting of liposomes to solid tumors along with the possible targets in cancer cells, i.e., extracellular and intracellular targets and targets in tumor microenvironment or vasculature.
Journal ArticleDOI
Display of GPI-anchored anti-EGFR nanobodies on extracellular vesicles promotes tumour cell targeting
Sander A.A. Kooijmans,Clara Gómez Aleza,Steve R. Roffler,Wouter W. van Solinge,Pieter Vader,Raymond M. Schiffelers +5 more
TL;DR: It is shown that nanobodies can be anchored on the surface of EVs via GPI, which alters their cell targeting behaviour and highlights GPI-anchoring as a new tool in the EV toolbox, which may be applied for EV display of a variety of proteins.
References
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Hallmarks of cancer: the next generation.
TL;DR: Recognition of the widespread applicability of these concepts will increasingly affect the development of new means to treat human cancer.
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A New Concept for Macromolecular Therapeutics in Cancer Chemotherapy: Mechanism of Tumoritropic Accumulation of Proteins and the Antitumor Agent Smancs
Yasuhiro Matsumura,Hiroshi Maeda +1 more
TL;DR: It is speculated that the tumoritropic accumulation of smancs and other proteins resulted because of the hypervasculature, an enhanced permeability to even macromolecules, and little recovery through either blood vessels or lymphatic vessels in tumors of tumor-bearing mice.
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Understanding biophysicochemical interactions at the nano–bio interface
Andre E. Nel,Lutz Mädler,Darrell Velegol,Tian Xia,Eric M.V. Hoek,Ponisseril Somasundaran,Fred Klaessig,Vince Castranova,Mike Thompson +8 more
TL;DR: Probing the various interfaces of nanoparticle/biological interfaces allows the development of predictive relationships between structure and activity that are determined by nanomaterial properties such as size, shape, surface chemistry, roughness and surface coatings.
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Understanding the nanoparticle-protein corona using methods to quantify exchange rates and affinities of proteins for nanoparticles.
Tommy Cedervall,Iseult Lynch,Stina Lindman,Tord Berggård,Eva Thulin,Hanna Nilsson,Kenneth A. Dawson,Sara Linse +7 more
TL;DR: The rates of protein association and dissociation are determined using surface plasmon resonance technology with nanoparticles that are thiol-linked to gold, and through size exclusion chromatography of protein–nanoparticle mixtures, and this method is developed into a systematic methodology to isolate nanoparticle-associated proteins.
Journal ArticleDOI
Knocking down barriers: advances in siRNA delivery
TL;DR: An update on the progress of RNAi therapeutics is provided and novel synthetic materials for the encapsulation and intracellular delivery of nucleic acids are highlighted.
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A New Concept for Macromolecular Therapeutics in Cancer Chemotherapy: Mechanism of Tumoritropic Accumulation of Proteins and the Antitumor Agent Smancs
Yasuhiro Matsumura,Hiroshi Maeda +1 more