C
Cornelia I. Bargmann
Researcher at Rockefeller University
Publications - 197
Citations - 44939
Cornelia I. Bargmann is an academic researcher from Rockefeller University. The author has contributed to research in topics: Caenorhabditis elegans & Gene. The author has an hindex of 106, co-authored 191 publications receiving 41310 citations. Previous affiliations of Cornelia I. Bargmann include Howard Hughes Medical Institute & University of California, San Francisco.
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Journal ArticleDOI
Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans
Coleen T. Murphy,Steven A. McCarroll,Cornelia I. Bargmann,Andrew G. Fraser,Ravi S. Kamath,Julie Ahringer,Hao Li,Cynthia Kenyon +7 more
TL;DR: The findings suggest that the insulin/IGF-I pathway ultimately exerts its effect on lifespan by upregulating a wide variety of genes, including cellular stress-response, antimicrobial and metabolic genes, and by downregulating specific life-shortening genes.
Journal ArticleDOI
Imaging neural activity in worms, flies and mice with improved GCaMP calcium indicators
Lin Tian,S. Andrew Hires,Tianyi Mao,Daniel Huber,M. Eugenia Chiappe,Sreekanth H. Chalasani,Leopoldo Petreanu,Jasper Akerboom,Sean A McKinney,Sean A McKinney,Eric R. Schreiter,Cornelia I. Bargmann,Vivek Jayaraman,Karel Svoboda,Loren L. Looger +14 more
TL;DR: A single-wavelength GCaMP2-based GECI (GCaMP3) is developed, with increased baseline fluorescence, increased dynamic range and higher affinity for calcium, and long-term imaging in the motor cortex of behaving mice revealed large fluorescence changes in imaged neurons over months.
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Mechanism of activation of a human oncogene.
Clifford J. Tabin,Scott M. Bradley,Cornelia I. Bargmann,Robert A. Weinberg,Alex G. Papageorge,Edward M. Scolnick,Ravi Dhar,Douglas R. Lowy,Esther H. Chang,Esther H. Chang +9 more
TL;DR: Experiments are presented that localize the genetic lesion that led to activation of the oncogene that affects the structure of theOncogene-encoded protein.
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Optimization of a GCaMP calcium indicator for neural activity imaging.
Jasper Akerboom,Tsai Wen Chen,Trevor J. Wardill,Lin Tian,Lin Tian,Jonathan S. Marvin,Sevinç Mutlu,Sevinç Mutlu,Nicole Carreras Calderón,Nicole Carreras Calderón,Nicole Carreras Calderón,Federico Esposti,Bart G. Borghuis,Bart G. Borghuis,Xiaonan Richard Sun,Andrew Gordus,Michael B. Orger,Michael B. Orger,Ruben Portugues,Florian Engert,John J. Macklin,Alessandro Filosa,Aman Aggarwal,Aman Aggarwal,Rex Kerr,Ryousuke Takagi,Sebastian Kracun,Eiji Shigetomi,Baljit S. Khakh,Herwig Baier,Leon Lagnado,Samuel S.-H. Wang,Cornelia I. Bargmann,Bruce E. Kimmel,Vivek Jayaraman,Karel Svoboda,Douglas S. Kim,Eric R. Schreiter,Eric R. Schreiter,Loren L. Looger +39 more
TL;DR: GCaMP5 fluorescence provides a more reliable measure of neuronal activity than its predecessor GCaMP3, which allows more sensitive detection of neural activity in vivo and may find widespread applications for cellular imaging in general.
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The neu oncogene encodes an epidermal growth factor receptor-related protein.
TL;DR: A neu complementary DNA clone isolated from a cell line transformed by this oncogene is decribed and suggests strongly that the neu gene encodes the receptor for an as yet unidentified growth factor.