E
Eric R. Schreiter
Researcher at Howard Hughes Medical Institute
Publications - 78
Citations - 16506
Eric R. Schreiter is an academic researcher from Howard Hughes Medical Institute. The author has contributed to research in topics: Calcium imaging & GCaMP. The author has an hindex of 35, co-authored 77 publications receiving 13438 citations. Previous affiliations of Eric R. Schreiter include Truman State University & University of Puerto Rico at Mayagüez.
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Journal ArticleDOI
Ultrasensitive fluorescent proteins for imaging neuronal activity.
Tsai Wen Chen,Trevor J. Wardill,Trevor J. Wardill,Yi Sun,Stefan R. Pulver,Sabine L. Renninger,Amy Baohan,Amy Baohan,Eric R. Schreiter,Rex Kerr,Michael B. Orger,Vivek Jayaraman,Loren L. Looger,Karel Svoboda,Douglas S. Kim +14 more
TL;DR: A family of ultrasensitive protein calcium sensors (GCaMP6) that outperformed other sensors in cultured neurons and in zebrafish, flies and mice in vivo are developed and provide new windows into the organization and dynamics of neural circuits over multiple spatial and temporal scales.
Journal ArticleDOI
Imaging neural activity in worms, flies and mice with improved GCaMP calcium indicators
Lin Tian,S. Andrew Hires,Tianyi Mao,Daniel Huber,M. Eugenia Chiappe,Sreekanth H. Chalasani,Leopoldo Petreanu,Jasper Akerboom,Sean A McKinney,Sean A McKinney,Eric R. Schreiter,Cornelia I. Bargmann,Vivek Jayaraman,Karel Svoboda,Loren L. Looger +14 more
TL;DR: A single-wavelength GCaMP2-based GECI (GCaMP3) is developed, with increased baseline fluorescence, increased dynamic range and higher affinity for calcium, and long-term imaging in the motor cortex of behaving mice revealed large fluorescence changes in imaged neurons over months.
Journal ArticleDOI
Optimization of a GCaMP calcium indicator for neural activity imaging.
Jasper Akerboom,Tsai Wen Chen,Trevor J. Wardill,Lin Tian,Lin Tian,Jonathan S. Marvin,Sevinç Mutlu,Sevinç Mutlu,Nicole Carreras Calderón,Nicole Carreras Calderón,Nicole Carreras Calderón,Federico Esposti,Bart G. Borghuis,Bart G. Borghuis,Xiaonan Richard Sun,Andrew Gordus,Michael B. Orger,Michael B. Orger,Ruben Portugues,Florian Engert,John J. Macklin,Alessandro Filosa,Aman Aggarwal,Aman Aggarwal,Rex Kerr,Ryousuke Takagi,Sebastian Kracun,Eiji Shigetomi,Baljit S. Khakh,Herwig Baier,Leon Lagnado,Samuel S.-H. Wang,Cornelia I. Bargmann,Bruce E. Kimmel,Vivek Jayaraman,Karel Svoboda,Douglas S. Kim,Eric R. Schreiter,Eric R. Schreiter,Loren L. Looger +39 more
TL;DR: GCaMP5 fluorescence provides a more reliable measure of neuronal activity than its predecessor GCaMP3, which allows more sensitive detection of neural activity in vivo and may find widespread applications for cellular imaging in general.
Journal ArticleDOI
IL-33 and ST2 comprise a critical biomechanically induced and cardioprotective signaling system
Shoji Sanada,Daihiko Hakuno,Luke J. Higgins,Eric R. Schreiter,Andrew Neil James Mckenzie,Richard T. Lee +5 more
TL;DR: IL-33/ST2 signaling is a mechanically activated, cardioprotective fibroblast-cardiomyocyte paracrine system, which is believed to be novel and may have therapeutic potential for beneficially regulating the myocardial response to overload.
Journal ArticleDOI
An optimized fluorescent probe for visualizing glutamate neurotransmission
Jonathan S. Marvin,Bart G. Borghuis,Bart G. Borghuis,Lin Tian,Lin Tian,Joseph Cichon,Mark T. Harnett,Jasper Akerboom,Andrew Gordus,Sabine L. Renninger,Tsai Wen Chen,Cornelia I. Bargmann,Michael B. Orger,Eric R. Schreiter,Jonathan B. Demb,Wen-Biao Gan,S. Andrew Hires,Loren L. Looger +17 more
TL;DR: An intensity-based glutamate-sensing fluorescent reporter with signal-to-noise ratio and kinetics appropriate for in vivo imaging is described and its utility for visualizing glutamate release by neurons and astrocytes in increasingly intact neurological systems is validated.