Dennis A. Aquino

TL;DR: There are different biological mechanisms for induction and maintenance of reactive gliosis, which, depending on the kind of tissue damage, result in different expressions of the gliotic response.

TL;DR: It is demonstrated that in glial cells, as well as other cell types, NOS-2 induction can be modulated by the HS response, mediated at least in part by HSP70 expression.

TL;DR: White matter undergoing immune-mediated destruction in MS was associated with altered distribution and expression of HSC70 and HSP27, which may initially serve to protect myelin from further destruction and facilitate repair, but may subsequently present as additional immune targets involved in the progression of disease.

TL;DR: Enhanced staining at the peak of the disease cannot be explained simply by an increase in antigen protein, as both the biochemical and immunocytochemical increases in GFAP persisted through 65 dpi, even though the animals recovered from clinical signs at approximately 18 dpi.

TL;DR: The results have shown that, whereas TNF had only a slight effect on vimentin mRNA, TNF induced a marked decrease to 4.3 ± 2.0% of controls in GFAP mRNA which was both time and dose dependent, which was not due to a generalized effect on intermediate filament metabolism.