D
Donna M. Rennick
Researcher at Schering-Plough
Publications - 27
Citations - 6916
Donna M. Rennick is an academic researcher from Schering-Plough. The author has contributed to research in topics: Nucleic acid & Interleukin 10. The author has an hindex of 13, co-authored 27 publications receiving 6704 citations. Previous affiliations of Donna M. Rennick include University of California, San Francisco & Merck & Co..
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Journal ArticleDOI
Requirement for IL-13 Independently of IL-4 in Experimental Asthma
Gabriele Grünig,Martha L. Warnock,Adil E. Wakil,Rajeev Venkayya,Frank Brombacher,Donna M. Rennick,Dean Sheppard,Markus Mohrs,Debra D. Donaldson,Richard M. Locksley,David B. Corry +10 more
TL;DR: This article showed that IL-4 receptor α chain-dependent pathway may underlie the genetic associations of asthma with both the human 5q31 locus and the IL4 receptor and showed that selective neutralization of IL-13, a cytokine related to interleukin-4 that also binds to the α chain of the IL 4 receptor, ameliorated asthma phenotype.
Journal ArticleDOI
Resident enteric bacteria are necessary for development of spontaneous colitis and immune system activation in interleukin-10-deficient mice.
Rance K. Sellon,Susan L. Tonkonogy,Michael Schultz,L. A. Dieleman,Wetonia B. Grenther,Ed Balish,Donna M. Rennick,Ryan Balfour Sartor +7 more
TL;DR: It is concluded that resident enteric bacteria are necessary for the development of spontaneous colitis and immune system activation in IL-10-deficient mice.
Journal ArticleDOI
Enterocolitis and colon cancer in interleukin-10 : deficient mice are associated with aberrant cytokine production and cd4+ th1-like responses
Daniel J. Berg,Natalle Davidson,Ralf Kühn,Werner Müller,Satish Menon,Gina Holland,Luann Thompson-Snipes,Michael W. Leach,Donna M. Rennick +8 more
TL;DR: The authors characterized the progressive stages of chronic intestinal inflammation that develops spontaneously in specific pathogen-free (SPF) mice with a targeted disruption in the IL-10 gene (IL-10-/-) and showed that inflammatory changes first appear in the cecum, ascending and transverse colon of 3-week-old mutants.
Journal ArticleDOI
Interleukin-10 is a central regulator of the response to LPS in murine models of endotoxic shock and the Shwartzman reaction but not endotoxin tolerance.
Daniel J. Berg,Ralf Kühn,Klaus Rajewsky,Werner Müller,Satish Menon,Natalie J. Davidson,Gabriele Grunig,Donna M. Rennick +7 more
TL;DR: Results show that IL-10 is a critical component of the host's natural defense against the development of pathologic responses to LPS although it is not responsible for LPS-induced tolerance.
Journal Article
Requirement for IL-13 independently of IL-4 in experimental asthma
Gabriele Grünig,Martha L. Warnock,Adil E. Wakil,Rajeev Venkayya,Frank Brombacher,Donna M. Rennick,Dean Sheppard,Markus Mohrs,Debra D. Donaldson,Richard M. Locksley,David B. Corry +10 more
TL;DR: Murine models support participation of interleukin-4 (IL-4) and the IL-4 receptor in asthma and selective neutralization of IL-13 ameliorated the asthma phenotype, including airway hyperresponsiveness, eosinophil recruitment, and mucus overproduction.