R
Rance K. Sellon
Researcher at North Carolina State University
Publications - 30
Citations - 2412
Rance K. Sellon is an academic researcher from North Carolina State University. The author has contributed to research in topics: Colitis & Feline immunodeficiency virus. The author has an hindex of 15, co-authored 28 publications receiving 2309 citations. Previous affiliations of Rance K. Sellon include North Carolina State University College of Veterinary Medicine & Washington State University.
Papers
More filters
Journal ArticleDOI
Resident enteric bacteria are necessary for development of spontaneous colitis and immune system activation in interleukin-10-deficient mice.
Rance K. Sellon,Susan L. Tonkonogy,Michael Schultz,L. A. Dieleman,Wetonia B. Grenther,Ed Balish,Donna M. Rennick,Ryan Balfour Sartor +7 more
TL;DR: It is concluded that resident enteric bacteria are necessary for the development of spontaneous colitis and immune system activation in IL-10-deficient mice.
Journal ArticleDOI
Impaired mucosal defense to acute colonic injury in mice lacking cyclooxygenase-1 or cyclooxygenase-2
Olivier Morteau,Scott G. Morham,Rance K. Sellon,Rance K. Sellon,L. A. Dieleman,Robert Langenbach,Oliver Smithies,R. Balfour Sartor +7 more
TL;DR: COX-1 and COX-2 share a crucial role in the defense of the intestinal mucosa (with inducible COX -2 being perhaps more active during inflammation) and that neither isoform is essential in maintaining mucosal homeostasis in the absence of injurious stimuli.
Journal ArticleDOI
Helicobacter hepaticus does not induce or potentiate colitis in interleukin-10-deficient mice.
L. A. Dieleman,A. Arends,Susan L. Tonkonogy,M. S. Goerres,D. W. Craft,W B Grenther,Rance K. Sellon,E. Balish,Ryan Balfour Sartor +8 more
TL;DR: It was found that IL-10−/− mice monoassociated with H. hepaticus for up to 16 weeks showed almost no histologic colitis or increased IL-12 production, and therefore is not required to induce colitis in genetically susceptible hosts.
Journal ArticleDOI
Intestinal inflammation reduces expression of DRA, a transporter responsible for congenital chloride diarrhea
Hongyun Yang,Wen Jiang,Emma E. Furth,Xiaoming Wen,Jonathan P. Katz,Rance K. Sellon,Debra G. Silberg,Toni M. Antalis,Clifford W. Schweinfest,Gary D. Wu +9 more
TL;DR: The loss of transport function in the surface epithelium of the colon by attenuation of transporter gene expression, perhaps inhibited at the level of gene transcription by proinflammatory cytokines, may play a role in the pathogenesis of diarrhea in colitis.