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Susan L. Tonkonogy
Researcher at North Carolina State University
Publications - Â 62
Citations - Â 4971
Susan L. Tonkonogy is an academic researcher from North Carolina State University. The author has contributed to research in topics: Colitis & Interleukin 10. The author has an hindex of 22, co-authored 59 publications receiving 4731 citations. Previous affiliations of Susan L. Tonkonogy include North Carolina State University College of Veterinary Medicine & University of North Carolina at Chapel Hill.
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Journal ArticleDOI
Resident enteric bacteria are necessary for development of spontaneous colitis and immune system activation in interleukin-10-deficient mice.
Rance K. Sellon,Susan L. Tonkonogy,Michael Schultz,L. A. Dieleman,Wetonia B. Grenther,Ed Balish,Donna M. Rennick,Ryan Balfour Sartor +7 more
TL;DR: It is concluded that resident enteric bacteria are necessary for the development of spontaneous colitis and immune system activation in IL-10-deficient mice.
Journal ArticleDOI
Variable phenotypes of enterocolitis in interleukin 10-deficient mice monoassociated with two different commensal bacteria
Sandra C. Kim,Susan L. Tonkonogy,Carol A. Albright,Julia Tsang,Edward Balish,Edward Balish,Jonathon Braun,Mark M. Huycke,R. Balfour Sartor +8 more
TL;DR: Different commensal bacterial species selectively initiate immune-mediated intestinal inflammation with distinctly different kinetics and anatomic distribution in the same host.
Journal ArticleDOI
Helper T-cell subsets: phenotype, function and the role of lymphokines in regulating their development.
Susan L. Swain,Linda M. Bradley,Michael Croft,Susan L. Tonkonogy,Gus Atkins,Andrew D. Weinberg,D D Duncan,Stephen M. Hedrick,Richard W. Dutton,Gail E. Huston +9 more
TL;DR: The studies suggest these emerging memory cells may be phenotypically unique and postulate that they are specialized to become a "long-lived" population of memory cells that will persist indefinitely as a protective population of increased frequency for the antigen encountered and which is also able to respond more rapidly and effectively.
Journal ArticleDOI
Lactobacillus plantarum 299V in the treatment and prevention of spontaneous colitis in interleukin-10-deficient mice.
Michael Schultz,Claudia Veltkamp,L. A. Dieleman,Wetonia B. Grenther,Pricilla B. Wyrick,Susan L. Tonkonogy,R. Balfour Sartor +6 more
TL;DR: Results demonstrate that L. plantarum can attenuate immune-mediated colitis and suggest a potential therapeutic role for this agent in clinical inflammatory bowel diseases.
Journal Article
Transforming growth factor-beta and IL-4 cause helper T cell precursors to develop into distinct effector helper cells that differ in lymphokine secretion pattern and cell surface phenotype.
TL;DR: The hypothesis that TGF-beta favors the development of a population(s) of Th cells that is likely to give rise to memory cells is proposed although IL-4 favorsDevelopment of a short-lived effector population that secretes Th2 lymphokines is proposed.