L
L. A. Dieleman
Researcher at University of North Carolina at Chapel Hill
Publications - 21
Citations - 3703
L. A. Dieleman is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Colitis & Cecum. The author has an hindex of 16, co-authored 21 publications receiving 3418 citations. Previous affiliations of L. A. Dieleman include University of Alberta.
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Journal ArticleDOI
Resident enteric bacteria are necessary for development of spontaneous colitis and immune system activation in interleukin-10-deficient mice.
Rance K. Sellon,Susan L. Tonkonogy,Michael Schultz,L. A. Dieleman,Wetonia B. Grenther,Ed Balish,Donna M. Rennick,Ryan Balfour Sartor +7 more
TL;DR: It is concluded that resident enteric bacteria are necessary for the development of spontaneous colitis and immune system activation in IL-10-deficient mice.
Journal ArticleDOI
Lactobacillus plantarum 299V in the treatment and prevention of spontaneous colitis in interleukin-10-deficient mice.
Michael Schultz,Claudia Veltkamp,L. A. Dieleman,Wetonia B. Grenther,Pricilla B. Wyrick,Susan L. Tonkonogy,R. Balfour Sartor +6 more
TL;DR: Results demonstrate that L. plantarum can attenuate immune-mediated colitis and suggest a potential therapeutic role for this agent in clinical inflammatory bowel diseases.
Journal ArticleDOI
Different subsets of enteric bacteria induce and perpetuate experimental colitis in rats and mice.
Heiko C. Rath,Michael Schultz,R Freitag,L. A. Dieleman,F. Li,H J Linde,J Schölmerich,Ryan Balfour Sartor +7 more
TL;DR: It is suggested that a subset of resident luminal bacteria induces colitis, but that a complex interaction of commensal aerobic and anaerobic bacteria provides the constant antigenic drive for chronic immune-mediated colonic inflammation.
Journal ArticleDOI
Impaired mucosal defense to acute colonic injury in mice lacking cyclooxygenase-1 or cyclooxygenase-2
Olivier Morteau,Scott G. Morham,Rance K. Sellon,Rance K. Sellon,L. A. Dieleman,Robert Langenbach,Oliver Smithies,R. Balfour Sartor +7 more
TL;DR: COX-1 and COX-2 share a crucial role in the defense of the intestinal mucosa (with inducible COX -2 being perhaps more active during inflammation) and that neither isoform is essential in maintaining mucosal homeostasis in the absence of injurious stimuli.
Journal ArticleDOI
Lactobacillus GG prevents recurrence of colitis in HLA-B27 transgenic rats after antibiotic treatment
L. A. Dieleman,M. S. Goerres,A. Arends,Dave Sprengers,C Torrice,Frank Hoentjen,W B Grenther,Ryan Balfour Sartor +7 more
TL;DR: It is suggested that antibiotics and probiotic agents provide synergistic therapeutic effects, perhaps mediated by altered immunomodulation with selective activity of different lactobacillus species in the prevention of recurrent colitis.