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Erlend A. Nagelhus
Researcher at University of Oslo
Publications - 80
Citations - 11737
Erlend A. Nagelhus is an academic researcher from University of Oslo. The author has contributed to research in topics: Aquaporin 4 & Water transport. The author has an hindex of 38, co-authored 78 publications receiving 9412 citations. Previous affiliations of Erlend A. Nagelhus include Aarhus University & University of Rochester.
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Journal ArticleDOI
A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β.
Jeffrey J. Iliff,Minghuan Wang,Minghuan Wang,Yonghong Liao,Benjamin A. Plogg,Weiguo Peng,Georg Andreas Gundersen,Helene Benveniste,G. Edward Vates,Rashid Deane,Steven A. Goldman,Erlend A. Nagelhus +11 more
TL;DR: An anatomically distinct clearing system in the brain that serves a lymphatic-like function is described and may have relevance for understanding or treating neurodegenerative diseases that involve the mis-accumulation of soluble proteins, such as amyloid β in Alzheimer's disease.
Journal ArticleDOI
Specialized membrane domains for water transport in glial cells : high-resolution immunogold cytochemistry of aquaporin-4 in rat brain
Søren Nielsen,Erlend A. Nagelhus,Mahmood Amiry-Moghaddam,Charles W. Bourque,Peter Agre,Ole Petter Ottersen +5 more
TL;DR: The highly polarized AQP4 expression indicates that these cells are equipped with specific membrane domains that are specialized for water transport, thereby mediating the flow of water between glial cells and the cavities filled with CSF and the intravascular space.
Journal ArticleDOI
Physiological Roles of Aquaporin-4 in Brain
TL;DR: A review will be provided of the physiological roles of AQP4 in brain and of the growing list of data that emphasize the polarized nature of astrocytes.
Journal ArticleDOI
Immunogold evidence suggests that coupling of K+ siphoning and water transport in rat retinal Müller cells is mediated by a coenrichment of Kir4.1 and AQP4 in specific membrane domains
Erlend A. Nagelhus,Yoshiyuki Horio,Atsushi Inanobe,Akikazu Fujita,Finn‐m. Haug,Søren Nielsen,Yoshihisa Kurachi,Ole Petter Ottersen +7 more
TL;DR: By its highly differentiated distribution of AQP4, the Müller cell may be able to direct the water flux to select extracellular compartments while protecting others (the subretinal space) from inappropriate volume changes.
Journal ArticleDOI
Aquaporin-4 in the central nervous system: Cellular and subcellular distribution and coexpression with KIR4.1
TL;DR: It is concluded that AQP4-mediated water flux represents an integral element of brain volume and ion homeostasis and contributes to the activity dependent volume changes of the extracellular space.