Yonghong Liao

TL;DR: An anatomically distinct clearing system in the brain that serves a lymphatic-like function is described and may have relevance for understanding or treating neurodegenerative diseases that involve the mis-accumulation of soluble proteins, such as amyloid β in Alzheimer's disease.

TL;DR: It is reported that sleep has a critical function in ensuring metabolic homeostasis and convective fluxes of interstitial fluid increased the rate of β-amyloid clearance during sleep, suggesting the restorative function of sleep may be a consequence of the enhanced removal of potentially neurotoxic waste products that accumulate in the awake central nervous system.

TL;DR: It is demonstrated that cerebral arterial pulsatility is a key driver of paravascular CSF influx into and through the brain parenchyma, and suggested that changes in arterials pulsatility may contribute to accumulation and deposition of toxic solutes, including amyloid β, in the aging brain.

TL;DR: It is shown in a murine TBI model that CSF movement through the recently characterized glymphatic pathway transports biomarkers to blood via the cervical lymphatics, and concludes that routine TBI patient management may limit the clinical utility of blood-based biomarkers because their brain-to-blood transport depends on Glymphatic activity.

TL;DR: It is shown that CSF-derived Aβ40 co-localizes with existing endogenous vascular and parenchymal amyloid-β plaques, and thus, may contribute to the progression of both cerebral amyloids angiopathy andparenchylal Aβ accumulation.