F
F. De Wolf
Researcher at Imperial College London
Publications - 111
Citations - 9811
F. De Wolf is an academic researcher from Imperial College London. The author has contributed to research in topics: Acquired immunodeficiency syndrome (AIDS) & Seroconversion. The author has an hindex of 44, co-authored 111 publications receiving 9620 citations. Previous affiliations of F. De Wolf include University College Dublin & Sanquin.
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Journal ArticleDOI
Inadequate maternal vascular response to placentation in pregnancies complicated by pre-eclampsia and by small-for-gestational age infants.
TL;DR: Findings point to a defect in the normal interaction between migratory trophoblast and maternal uterine tissues in pre‐eclampsia and in SGA, a feature not seen beyond the second trimester in normal pregnancy.
Journal ArticleDOI
Evidence for a role of virulent human immunodeficiency virus (HIV) variants in the pathogenesis of acquired immunodeficiency syndrome: studies on sequential HIV isolates.
M. Tersmette,Rob A. Gruters,F. De Wolf,R. E. Y. De Goede,J. M. A. Lange,Peter Th. A. Schellekens,Jaap Goudsmit,H. G. Huisman,Frank Miedema +8 more
TL;DR: Findings indicate that variability in the biological properties of HIV isolates is one of the factors influencing the course of HIV infection.
Journal ArticleDOI
Association between biological properties of human immunodeficiency virus variants and risk for AIDS and AIDS mortality.
M. Tersmette,J M Lange,R. E. Y. De Goede,F. De Wolf,J. K. Eeftink-Schattenkerk,Peter Th. A. Schellekens,R. A. Coutinho,J. G. Huisman,Jaap Goudsmit,Frank Miedema +9 more
TL;DR: Zidovudine treatment in the symptom-free period seemed to delay the onset of AIDS in all risk groups, although stabilisation of CD4+ cell numbers was observed only in individuals with non-syncytium-inducing HIV variants.
Journal ArticleDOI
Immunological abnormalities in human immunodeficiency virus (HIV)-infected asymptomatic homosexual men. HIV affects the immune system before CD4+ T helper cell depletion occurs.
Frank Miedema,A J Petit,F G Terpstra,J K Schattenkerk,F. De Wolf,B. J. M. Al,Marijke T. L. Roos,Johan Lange,Sven A. Danner,Jaap Goudsmit +9 more
TL;DR: HIV induces severe immunological abnormalities in T cells, B cells, and antigen-presenting cells early in infection before CD4+ T cell numbers start to decline, suggesting that impaired immunological function in subclinically HIV- infected patients may have clinical implications for vaccination strategies.
Journal ArticleDOI
Late presentation of HIV infection: a consensus definition
Andrea Antinori,T Coenen,D Costagiola,N. Dedes,M. Ellefson,Jose M. Gatell,Enrico Girardi,Margaret Johnson,Ole Kirk,Jens D Lundgren,Amanda Mocroft,A d'Arminio Monforte,Andrew N. Phillips,Dorthe Raben,Jürgen K. Rockstroh,Caroline A. Sabin,Anders Sönnerborg,F. De Wolf +17 more
TL;DR: A consensus definition of late presentation of HIV infection is presented to present to identify the extent to which late presentation occurs remains inadequate across Europe.