G
Gui Yao
Publications - 2
Citations - 317
Gui Yao is an academic researcher. The author has contributed to research in topics: IDH1 & Mutant. The author has an hindex of 2, co-authored 2 publications receiving 210 citations.
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Journal ArticleDOI
Discovery of AG-120 (Ivosidenib): A First-in-Class Mutant IDH1 Inhibitor for the Treatment of IDH1 Mutant Cancers
Janeta Popovici-Muller,Lemieux Rene M,Erin Artin,Jeffrey O. Saunders,Francesco G. Salituro,Jeremy Travins,Giovanni Cianchetta,Zhenwei Cai,Ding Zhou,Cui Dawei,Ping Chen,Kimberly Straley,Erica Tobin,Fang Wang,Muriel D. David,Virginie Penard-Lacronique,Cyril Quivoron,Véronique Saada,Stéphane de Botton,Stefan Gross,Lenny Dang,Hua Yang,Luke Utley,Yue Chen,Hyeryun Kim,Shengfang Jin,Zhiwei Gu,Gui Yao,Zhiyong Luo,Xiaobing Lv,Cheng Fang,Liping Yan,Andrew J. Olaharski,Lee Silverman,Scott A. Biller,Shinsan M. Su,Katharine E. Yen +36 more
TL;DR: AG-120 (ivosidenib), an inhibitor of the IDH1 mutant enzyme that exhibits profound 2-HG lowering in tumor models and the ability to effect differentiation of primary patient AML samples ex vivo is reported.
Journal ArticleDOI
AG-348 enhances pyruvate kinase activity in red blood cells from patients with pyruvate kinase deficiency
Charles Kung,Jeff Hixon,Penelope A. Kosinski,Giovanni Cianchetta,Gavin Histen,Yue Chen,Collin Hill,Stefan Gross,Yaguang Si,Kendall Johnson,Byron DeLaBarre,Zhiyong Luo,Zhiwei Gu,Gui Yao,Huachun Tang,Cheng Fang,Yingxia Xu,Xiaobing Lv,Scott A. Biller,Shin-San Michael Su,Hua Yang,Janeta Popovici-Muller,Francesco G. Salituro,Lee Silverman,Lenny Dang +24 more
TL;DR: It is demonstrated that AG-348 can increase the activity of wild-type and mutant PK enzymes in biochemical assays and in patient red blood cells treated ex vivo, illustrating the potential for AG- 348 to restore the glycolytic pathway activity in patients with PK deficiency and ultimately lead to clinical benefit.