Liping Yan

TL;DR: AG-120 (ivosidenib), an inhibitor of the IDH1 mutant enzyme that exhibits profound 2-HG lowering in tumor models and the ability to effect differentiation of primary patient AML samples ex vivo is reported.

TL;DR: Wang et al. as discussed by the authors identified the active ingredients and elucidated the underlying mechanism of action of Atractylodes lancea (Thunb.) DC (namely, Cangzhu) for the treatment of gouty arthritis (GA) based on network pharmacology methods.

TL;DR: The results showed that SGN exerted a certain gastroprotective effect via multiple pathways and targets, mainly caused by the key active ingredients isofraxidin, rosmarinic, and caffeic acid, which regulate hub targets, which maintain the homeostasis of related metabolites.

TL;DR: In this article , a metabolomic analysis showed that metformin significantly increased the accumulation of tauroursodeoxycholic acid (TUDCA) in intestine and liver from high-fat diet (HFD)-induced type 2 diabetes mice.

TL;DR: In this paper , an orally bioavailable small-molecule inhibitor of PCSK9 with significant cholesterol-lowering activity in hyperlipidemic APOE∗3-Leiden mice was presented.