Helin Koc

TL;DR: Data appear to favor the hypothesis that short-term effects visible in breath isoprene levels are mainly caused by changes in pulmonary gas exchange patterns rather than fluctuations in endogenous synthesis, and hold great potential in capturing continuous dynamics of non-polar, low-soluble VOCs over a wide measurement range.

TL;DR: A thorough modeling study of the end-tidal breath dynamics associated with isoprene, which serves as a paradigmatic example for the class of low-soluble, blood-borne VOCs, is devoted to aid further investigations regarding the exhalation, storage, transport and biotransformation processes associated with this important compound.

TL;DR: In this article, the authors developed a compartment model that reliably captures these profiles and is capable of relating breath to the systemic concentrations of acetone, with minimal changes of the underlying blood and tissue concentrations.

TL;DR: The chief intention of the present modeling study is to provide mechanistic relationships for further investigating the exhalation kinetics of acetone and other water-soluble species, and is a first step towards new guidelines for breath gas analyses of volatile organic compounds, similar to those for nitric oxide.

TL;DR: It is demonstrated that the end-tidal breath profiles of such substances during isothermal rebreathing show a characteristic increase that contradicts the conventional pulmonary inert gas elimination theory due to Farhi, and a previously developed mathematical model for the general exhalation kinetics of highly soluble, blood-borne VOCs is used.