H
Heng Zhang
Researcher at Chinese Academy of Sciences
Publications - Â 63
Citations - Â 5456
Heng Zhang is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: DNA methylation & Gene. The author has an hindex of 29, co-authored 51 publications receiving 3687 citations. Previous affiliations of Heng Zhang include Purdue University & Center for Excellence in Education.
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Journal ArticleDOI
The CRISPR/Cas9 system produces specific and homozygous targeted gene editing in rice in one generation
Hui Zhang,Jinshan Zhang,Pengliang Wei,Botao Zhang,Feng Gou,Zhengyan Feng,Yanfei Mao,Lan Yang,Heng Zhang,Nanfei Xu,Jian-Kang Zhu,Jian-Kang Zhu +11 more
TL;DR: In this paper, the CRISPR/Cas9-induced gene mutations in Arabidopsis were mostly somatic mutations in the early generation, although some mutations could be stably inherited in later generations.
Journal ArticleDOI
Circulating tumour DNA methylation markers for diagnosis and prognosis of hepatocellular carcinoma
Rui-Hua Xu,Wei Wei,Wei Wei,Michal Krawczyk,Wenqiu Wang,Huiyan Luo,Huiyan Luo,Ken Flagg,Shaohua Yi,William Shi,Qingli Quan,Kang Li,Lianghong Zheng,Heng Zhang,Bennett A. Caughey,Qi Zhao,Jiayi Hou,Runze Zhang,Yanxin Xu,Huimin Cai,Gen Li,Rui Hou,Zheng Zhong,Danni Lin,Xin Fu,Jie Zhu,Yaou Duan,Meixing Yu,Binwu Ying,Wengeng Zhang,Juan Wang,Edward Zhang,Charlotte Zhang,Oulan Li,Rongping Guo,Hannah Carter,Jian-Kang Zhu,Xiaoke Hao,Kang Zhang,Kang Zhang,Kang Zhang +40 more
TL;DR: This work identified an HCC-specific methylation marker panel by comparing HCC tissue and normal blood leukocytes and showed that methylation profiles of HCC tumour DNA and matched plasma ctDNA are highly correlated.
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Mechanisms of Plant Responses and Adaptation to Soil Salinity.
Chunzhao Zhao,Chunzhao Zhao,Heng Zhang,Chun-Peng Song,Jian-Kang Zhu,Jian-Kang Zhu,Sergey Shabala,Sergey Shabala +7 more
TL;DR: This review provides a comprehensive summary of the mechanisms of salt stress responses in plants, including salt stress-triggered physiological responses, oxidative stress, salt stress sensing and signaling pathways, organellar stress, ion homeostasis, hormonal and gene expression regulation, metabolic changes, as well as salt tolerance mechanisms in halophytes.
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Comparative physiological, metabolomic, and transcriptomic analyses reveal mechanisms of improved abiotic stress resistance in bermudagrass [Cynodon dactylon (L). Pers.] by exogenous melatonin
Haitao Shi,Chuan Jiang,Tiantian Ye,Dun Xian Tan,Russel J. Reiter,Heng Zhang,Renyi Liu,Zhulong Chan +7 more
TL;DR: Exogenous melatonin application confers abiotic stress resistance in bermudagrass through modulation of antioxidants and metabolic homeostasis, and extensive transcriptional reprogramming such as the reorientation of photorespiratory, carbohydrate, and nitrogen metabolism.
Journal ArticleDOI
DNA methylation markers for diagnosis and prognosis of common cancers.
Xiaoke Hao,Huiyan Luo,Michal Krawczyk,Wei Wei,Wei Wei,Wenqiu Wang,Juan Wang,Ken Flagg,Jiayi Hou,Heng Zhang,Shaohua Yi,Maryam Jafari,Danni Lin,Christopher Chung,Bennett A. Caughey,Gen Li,Debanjan Dhar,William Shi,Lianghong Zheng,Rui Hou,Jie Zhu,Liang Zhao,Xin Fu,Edward Zhang,Charlotte Zhang,Jian-Kang Zhu,Michael Karin,Rui-Hua Xu,Kang Zhang +28 more
TL;DR: The utility of DNA methylation profiles for differentiating tumors and normal tissues for four common cancers found that they could differentiate cancerous tissue from normal tissue with >95% accuracy and can predict prognosis and survival.