H
Hubert G. M. Leufkens
Researcher at Utrecht University
Publications - 552
Citations - 24739
Hubert G. M. Leufkens is an academic researcher from Utrecht University. The author has contributed to research in topics: Population & Odds ratio. The author has an hindex of 74, co-authored 538 publications receiving 22557 citations. Previous affiliations of Hubert G. M. Leufkens include European Medicines Agency & University of Southampton.
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Journal ArticleDOI
The epidemiology of corticosteroid-induced osteoporosis: a meta-analysis.
TL;DR: It is concluded that oral corticosteroid treatment using more than 5 mg (of prednisolone or equivalent) daily leads to a reduction in bone mineral density and a rapid increase in the risk of fracture during the treatment period.
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A comparison of measures of disproportionality for signal detection in spontaneous reporting systems for adverse drug reactions.
Eugène van Puijenbroek,Andrew Bate,Andrew Bate,Hubert G. M. Leufkens,Marie Lindquist,Roland Orre,Antoine C. G. Egberts +6 more
TL;DR: The objective of this study is to examine the level of concordance of the various estimates to the measure used by the WHO Collaborating Centre for International ADR monitoring, the information component (IC), when applied to the dataset of the Netherlands Pharmacovigilance Foundation Lareb.
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Oral corticosteroids and fracture risk: relationship to daily and cumulative doses
TL;DR: The findings suggest that the adverse skeletal effects of oral corticosteroids manifest rapidly and are related to daily dose, and Preventive measures against cortICosteroid-induced osteoporosis should be instituted as soon after the commencement of glucocorticoid therapy as possible.
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Clinical assessment of the long-term risk of fracture in patients with rheumatoid arthritis
TL;DR: Patients with rheumatoid arthritis are at increased risk of osteoporotic fractures, which is attributable to a combination of disease activity and use of oral glucocorticoids.
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Dronedarone in High-Risk Permanent Atrial Fibrillation
TL;DR: Dronedarone increased rates of heart failure, stroke, and death from cardiovascular causes in patients with permanent atrial fibrillation who were at risk for major vascular events and should not be used in such patients.