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Igor A. Sidorov
Researcher at Leiden University
Publications - 7
Citations - 5540
Igor A. Sidorov is an academic researcher from Leiden University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 1, co-authored 1 publications receiving 3790 citations.
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The species Severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2
Alexander E. Gorbalenya,Susan C. Baker,Ralph S. Baric,Raoul J. de Groot,Christian Drosten,Anastasia A. Gulyaeva,Bart L. Haagmans,Chris Lauber,Andrey M. Leontovich,Benjamin W. Neuman,Dmitry Penzar,Stanley Perlman,Leo L.M. Poon,Dmitry V. Samborskiy,Igor A. Sidorov,Isabel Sola,John Ziebuhr +16 more
TL;DR: The independent zoonotic transmission of SARS-CoV and SARS -CoV-2 highlights the need for studying viruses at the species level to complement research focused on individual pathogenic viruses of immediate significance.
Journal ArticleDOI
Immune Determinants of Viral Clearance in Hospitalised COVID-19 Patients: Reduced Circulating Naïve CD4+ T Cell Counts Correspond with Delayed Viral Clearance
Mihaela Zlei,Igor A. Sidorov,Simone A. Joosten,Mirjam H.M. Heemskerk,Sebenzile K. Myeni,Cilia R. Pothast,Caroline S. de Brouwer,A. Linda Boomaars-van der Zanden,Krista E. van Meijgaarden,S. T. Morales,Els Wessels,Jacqueline J. Janse,Jelle J. Goeman,Christa M. Cobbaert,Aloys C.M. Kroes,Suzanne C. Cannegieter,Meta Roestenberg,Leo G. Visser,Marjolein Kikkert,Mariet C.W. Feltkamp,Sesmu M. Arbous,Frank J. T. Staal,Tom H. M. Ottenhoff,J. J. M. Van Dongen,Anna H. Roukens,Jutte J.C. de Vries,In Collaboration With Beat-Covid,In Collaboration With Lumc Covid +27 more
TL;DR: Data show that naïve CD4+ T cell play a critical role in rapid viral T cell control, obviating aberrant antibody and cytokine profiles and disease deterioration, and may help in guiding risk stratification for severe COVID-19.
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Genome-wide diversity of Zika virus: Exploring spatio-temporal dynamics to guide a new nomenclature proposal
Sofia G. Seabra,Pieter Libin,Kristof Theys,Anna Zhukova,Barney Potter,Hanna Nebenzahl-Guimaraes,Alexander E. Gorbalenya,Igor A. Sidorov,Victor Pimentel,Marta Pingarilho,Ana Tereza Ribeiro de Vasconcelos,Simon Dellicour,Ricardo Khouri,Olivier Gascuel,Anne-Mieke Vandamme,Guy Baele,Lize Cuypers,Ana B. Abecasis +17 more
TL;DR: To characterize ZikV genetic diversity and phylodynamics, identify genomic footprints of differentiation patterns, and propose a dynamic classification system that reflects its divergence levels, a curated dataset of 762 publicly available sequences spanning the full-length coding region of ZIKV was analysed.
Journal ArticleDOI
Performance of Five Metagenomic Classifiers for Virus Pathogen Detection Using Respiratory Samples from a Clinical Cohort
Ellen C Carbo,Igor A. Sidorov,Anneloes L. van Rijn-Klink,Nikos Pappas,Sander van Boheemen,Hailiang Mei,Pieter S. Hiemstra,Tomas Mikal Eagan,Eric C. J. Claas,Aloys C.M. Kroes,Jutte J.C. de Vries +10 more
TL;DR: Sensitivity and specificity were within the ranges of use for diagnostic practice when the cut-off for defining a positive result was considered per classifier, and was dependent on the classification level and data pre-processing.
Journal ArticleDOI
Non-Toxigenic Clostridioides difficile Strain E4 (NTCD-E4) Prevents Establishment of Primary C. difficile Infection by Epidemic PCR Ribotype 027 in an In Vitro Human Gut Model
Perezimor Etifa,César Rodríguez,Celine Harmanus,Ingrid M J G Sanders,Igor A. Sidorov,Olufunmilayo Mohammed,Emily Savage,Andrew R. Timms,Jane Freeman,Wiep Klaas Smits,Mark H. Wilcox,Simon D. Baines +11 more
TL;DR: In this article , the efficacy of metronidazole-resistant NTCD-E4 in preventing CDI facilitated by a range of antimicrobials in an in vitro human gut model was evaluated.