Ilaria Roglio

TL;DR: The hypothesis that neuroactive steroids might represent a new therapeutic strategy for peripheral neuropathy is proposed.

TL;DR: Chronic treatment with progesterone, dihydroprogesterone or its derivatives, DHP and THP, counteracted the impairment of nerve conduction velocity and thermal threshold, restored skin innervation density, and improved Na(+),K(+)-ATPase activity and mRNA levels of myelin proteins, suggesting that these neuroactive steroids, might be useful protective agents in diabetic neuropathy.

TL;DR: Observations suggest that DHP and P (i.e. two neuroactive steroids interacting with progesterone receptor) may be considered protective agents in case of nerve crush injury.

TL;DR: It is demonstrated that the LC-MS/MS method allows the assessment of neuroactive steroids in the nervous system with high sensitivity and specificity and that diabetes strongly affects their levels, providing a further basis for new therapeutic tools based on neuro active steroids aimed at counteracting diabetic neuropathy.

TL;DR: Observations here summarized indicate that neuroactive steroids, such as progesterone, testosterone and their reduced metabolites, might represent a promising therapeutic option for the treatment of different forms of peripheral neuropathy.