Journal ArticleDOI
Neuroactive steroids: A therapeutic approach to maintain peripheral nerve integrity during neurodegenerative events.
E. Leonelli,M. Ballabio,Antonio Consoli,Ilaria Roglio,Valerio Magnaghi,Roberto Cosimo Melcangi +5 more
TLDR
The hypothesis that neuroactive steroids might represent a new therapeutic strategy for peripheral neuropathy is proposed.Abstract:
It is now well known that peripheral nerves are a target for the action of neuroactive steroids. This review summarizes observations obtained so far, indicating that through the interaction with classical and nonclassical steroid receptors, neuroactive steroids (e.g., progesterone, testosterone and their derivatives, estrogens, etc.) are able to influence several parameters of the peripheral nervous system, particularly its glial compartment (i.e., Schwann cells). Interestingly, some of these neuroactive steroids might be considered as promising neuroprotective agents. They are able to counteract neurodegenerative events of rat peripheral nerves occurring after experimental physical trauma, during the aging process, or in hereditary demyelinating diseases. On this basis, the hypothesis that neuroactive steroids might represent a new therapeutic strategy for peripheral neuropathy is proposed.read more
Citations
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Neurosteroids: endogenous regulators of the GABAA receptor
Delia Belelli,Jeremy J. Lambert +1 more
TL;DR: GABAA (γ-aminobutyric acid type A) receptors mediate most of the 'fast' synaptic inhibition in the mammalian brain and are targeted by many clinically important drugs.
Journal ArticleDOI
International Union of Pharmacology. LXX. Subtypes of γ-Aminobutyric AcidA Receptors: Classification on the Basis of Subunit Composition, Pharmacology, and Function. Update
Richard W. Olsen,Werner Sieghart +1 more
TL;DR: This review attempts to summarize experimental evidence on the existence of defined native GABAA receptor subtypes and to produce a list of receptors that actually seem to exist according to current knowledge, and proposes several criteria, which can be applied to all the members of the LGIC superfamily, for including a receptor subtype on a lists of native hetero-oligomeric subtypes.
Journal ArticleDOI
Minireview: rapid glucocorticoid signaling via membrane-associated receptors.
TL;DR: A brief review focused on multiple lines of evidence suggesting that rapid glucocorticoid actions are triggered by, or at least dependent on, membrane-associated G protein-coupled receptors and activation of downstream signaling cascades is provided.
Journal ArticleDOI
Molecular Mechanisms and Therapeutic Targets in Steatosis and Steatohepatitis
Nora Anderson,Jürgen Borlak +1 more
TL;DR: The contribution of cytokines and other signaling molecules, as well as activity of nuclear receptors, lipids, transcription factors, and endocrine mediators toward cellular dysfunction and progression of steatotic liver disease to NASH is specifically addressed, as is the cross-talk of different cell types in the pathogenesis of NAFLD.
Journal ArticleDOI
Anxiety disorders and GABA neurotransmission: a disturbance of modulation
TL;DR: The concept of anxiety disorders as a disturbance of emotional response regulation is a useful one as it allows anxiety to be explained in terms of a more general model of aberrant salience and also because it identifies avenues for developing psychological, behavioral, and pharmacological strategies for the treatment of anxiety disorder.
References
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Journal ArticleDOI
Influence of aging on peripheral nerve function and regeneration.
TL;DR: Age-related changes are not linearly progressive with age; the capabilities for axonal regeneration and reinnervation are maintained throughout life, but tend to be delayed and less effective with aging.
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Ion channels in glial cells.
TL;DR: This review shall give a comprehensive summary of the main functional properties of ion channels and ionotropic receptors expressed by macroglial cells, i.e., by astrocytes, oligodendrocycles and Schwann cells, as well as glutamate, GABA and ATP activated ionotropic receptor.
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Mouse P0 gene disruption leads to hypomyelination, abnormal expression of recognition molecules, and degeneration of myelin and axons
TL;DR: It is demonstrated that P0 is essential for the normal spiraling, compaction, and maintenance of the peripheral myelin sheath and the continued integrity of associated axons and suggested that this protein conveys a signal that regulates Schwann cell gene expression.
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Neurosteroid modulation of GABAA receptors.
TL;DR: Emerging evidence is reviewed that the GABA-modulatory actions of the pregnane steroids are highly selective, with their actions being brain region and indeed neuron dependent, and the sensitivity of GABA(A) receptors is not static but can dynamically change.
Journal ArticleDOI
Progesterone synthesis and myelin formation by Schwann cells
H. Koenig,Michael Schumacher,Badia Ferzaz,Anh N. Do Thi,Annie Ressouches,Rachida Guennoun,Ingrid Jung-Testas,Paul Robel,Yvette Akwa,Etienne-Emile Baulieu,Etienne-Emile Baulieu +10 more
TL;DR: It is demonstrated that progesterone is not simply a sex steroid, and a new therapeutic approach is suggested to promote myelin repair in male mice after cryolesion of the sciatic nerve.