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Roberto Cosimo Melcangi

Researcher at University of Milan

Publications -  223
Citations -  10645

Roberto Cosimo Melcangi is an academic researcher from University of Milan. The author has contributed to research in topics: Neuroactive steroid & Myelin. The author has an hindex of 61, co-authored 212 publications receiving 9773 citations. Previous affiliations of Roberto Cosimo Melcangi include Center for Excellence in Education & National Cancer Research Institute.

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Journal ArticleDOI

Neuroactive steroids: A therapeutic approach to maintain peripheral nerve integrity during neurodegenerative events.

E. Leonelli, +5 more
- 01 Jan 2006 - 
TL;DR: The hypothesis that neuroactive steroids might represent a new therapeutic strategy for peripheral neuropathy is proposed.
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Steroid hormones and neurosteroids in normal and pathological aging of the nervous system

Martin Schumacher, +13 more
- 01 Sep 2003 - 
TL;DR: In Alzheimer's patients, there was a general trend toward lower levels of neurosteroids in different brain regions, and neurosteroid levels were negatively correlated with two biochemical markers of Alzheimer's disease, the phosphorylated tau protein and the beta-amyloid peptides.
Journal Article

The 5 alpha-reductase in the brain: molecular aspects and relation to brain function.

Fabio Celotti, +2 more
- 01 Apr 1992 - 
TL;DR: One of the two major enzymatic systems that transform steroids in the brain is analyzed, namely the 5 alpha-reductase-3 alpha-(3 beta)-hydroxysteroid dehydrogenase pathway, which is widely distributed in practically all CNS structures in all phases of development.
Journal ArticleDOI

Neuroactive steroids: State of the art and new perspectives

Roberto Cosimo Melcangi, +2 more
- 01 Mar 2008 - 
TL;DR: The fundamental evidence and knowledge gained constitute a profound background that offers interesting possibilities for developing effective strategies against several disorders of the nervous system, and the pleiotropic and protective abilities of neuroactive steroids.
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Glia-neuron crosstalk in the neuroprotective mechanisms of sex steroid hormones.

Daniel Garcia-Ovejero, +4 more
- 01 Apr 2005 - 
TL;DR: Proteins involved in the intramitochondrial trafficking of cholesterol, the first step in steroidogenesis, are upregulated in the nervous system after injury, and a local increase in the levels of steroids is observed following traumatic injury in the brain and spinal cord.