Valerio Magnaghi

TL;DR: The hypothesis that neuroactive steroids might represent a new therapeutic strategy for peripheral neuropathy is proposed.

TL;DR: The present review will focus on the role of metabotropic glutamate receptors and GABA receptors in the modulation of pain perception.

TL;DR: Chronic treatment with progesterone, dihydroprogesterone or its derivatives, DHP and THP, counteracted the impairment of nerve conduction velocity and thermal threshold, restored skin innervation density, and improved Na(+),K(+)-ATPase activity and mRNA levels of myelin proteins, suggesting that these neuroactive steroids, might be useful protective agents in diabetic neuropathy.

TL;DR: The data suggest that P, DHP and THP may represent useful therapeutic alternatives to maintain peripheral nerve integrity in aged animals and reduce aging-associated morphological abnormalities of myelin and aging- associated myelin fiber loss in the sciatic nerve.

TL;DR: It is hypothesize that NO/NOS and IL‐1β have a pronociceptive role in this neuropathy model, and that purinergic antagonism reduces pain hypersensitivity by inhibiting their overactivity.