J
Janna K. Mouw
Researcher at University of California, San Francisco
Publications - 27
Citations - 5503
Janna K. Mouw is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Extracellular matrix & Biology. The author has an hindex of 17, co-authored 21 publications receiving 4380 citations. Previous affiliations of Janna K. Mouw include Georgia Institute of Technology & Parker H. Petit Institute for Bioengineering & Bioscience.
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Journal ArticleDOI
The extracellular matrix modulates the hallmarks of cancer
TL;DR: It is suggested that the success of cancer prevention and therapy programs requires an intimate understanding of the reciprocal feedback between the evolving extracellular matrix, the tumor cells and its cancer‐associated cellular stroma.
Journal ArticleDOI
Extracellular matrix assembly: a multiscale deconstruction
TL;DR: The product is a specific ECM signature that is comprised of unique compositional and topographical features that both reflect and facilitate the functional requirements of the tissue.
Journal ArticleDOI
The cancer glycocalyx mechanically primes integrin-mediated growth and survival
Matthew J. Paszek,Christopher C. DuFort,Olivier Rossier,Russell Bainer,Janna K. Mouw,Kamil Godula,Jason E. Hudak,Jonathon N. Lakins,Amanda C. Wijekoon,Luke Cassereau,Matthew G. Rubashkin,Mark Jesus M. Magbanua,Kurt S. Thorn,Michael W. Davidson,Hope S. Rugo,John W. Park,Daniel A. Hammer,Grégory Giannone,Carolyn R. Bertozzi,Valerie M. Weaver +19 more
TL;DR: A bulky glycocalyx is a feature of tumour cells that could foster metastasis by mechanically enhancing cell-surface receptor function by increasing integrin adhesion and signalling.
Journal ArticleDOI
Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression.
Hanane Laklai,Yekaterina A. Miroshnikova,Michael W. Pickup,Eric A. Collisson,Grace E. Kim,Alexander S. Barrett,Ryan C. Hill,Johnathon N. Lakins,David D. Schlaepfer,Janna K. Mouw,Valerie S. LeBleu,Nilotpal Roy,Sergey V. Novitskiy,Julia S. Johansen,Valeria Poli,Raghu Kalluri,Christine A. Iacobuzio-Donahue,Laura D. Wood,Matthias Hebrok,Kirk C. Hansen,Harold L. Moses,Valerie M. Weaver +21 more
TL;DR: The findings implicate epithelial tension and matricellular fibrosis in the aggressiveness of SMAD4 mutant pancreatic tumors and highlight STAT3 and mechanics as key drivers of this phenotype.
Journal ArticleDOI
Tissue mechanics modulate microRNA-dependent PTEN expression to regulate malignant progression
Janna K. Mouw,Yoshihiro Yui,Laura Damiano,Russell Bainer,Johnathon N. Lakins,Irene Acerbi,Guanqing Ou,Amanda C. Wijekoon,Kandice R. Levental,Penney M. Gilbert,E. Shelley Hwang,Yunn Yi Chen,Valerie M. Weaver +12 more
TL;DR: This work demonstrates that increased matrix stiffness modulates microRNA expression to drive tumor progression through integrin activation of β-catenin and MYC and identifies a mechanically regulated microRNA circuit that can promote malignancy and suggest potential prognostic roles for HOXA9 and miR-18a levels in stratifying patients with luminal breast cancers.