M
Michael W. Pickup
Researcher at University of California, San Francisco
Publications - 38
Citations - 4507
Michael W. Pickup is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Tumor microenvironment & Metastasis. The author has an hindex of 25, co-authored 35 publications receiving 3607 citations. Previous affiliations of Michael W. Pickup include Vanderbilt University & Vanderbilt University Medical Center.
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Journal ArticleDOI
The extracellular matrix modulates the hallmarks of cancer
TL;DR: It is suggested that the success of cancer prevention and therapy programs requires an intimate understanding of the reciprocal feedback between the evolving extracellular matrix, the tumor cells and its cancer‐associated cellular stroma.
Journal ArticleDOI
The roles of TGFβ in the tumour microenvironment
TL;DR: The role of an essential signalling pathway, that of transforming growth factor-β, in the regulation of components of the tumour microenvironment and how this contributes to tumour progression is addressed.
Journal ArticleDOI
Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression.
Hanane Laklai,Yekaterina A. Miroshnikova,Michael W. Pickup,Eric A. Collisson,Grace E. Kim,Alexander S. Barrett,Ryan C. Hill,Johnathon N. Lakins,David D. Schlaepfer,Janna K. Mouw,Valerie S. LeBleu,Nilotpal Roy,Sergey V. Novitskiy,Julia S. Johansen,Valeria Poli,Raghu Kalluri,Christine A. Iacobuzio-Donahue,Laura D. Wood,Matthias Hebrok,Kirk C. Hansen,Harold L. Moses,Valerie M. Weaver +21 more
TL;DR: The findings implicate epithelial tension and matricellular fibrosis in the aggressiveness of SMAD4 mutant pancreatic tumors and highlight STAT3 and mechanics as key drivers of this phenotype.
Journal ArticleDOI
Gr-1+CD11b+ Myeloid Cells Tip the Balance of Immune Protection to Tumor Promotion in the Premetastatic Lung
Hannah Yan,Michael W. Pickup,Yanli Pang,Agnieszka E. Gorska,Zhaoyang Li,Anna Chytil,Yipeng Geng,Jerome W. Gray,Harold L. Moses,Li Yang +9 more
TL;DR: Inhibition of Gr-1+CD11b+ cells could normalize the premetastatic lung environment, improve host immunosurveillance, and inhibit tumor metastasis.
Journal ArticleDOI
Tissue mechanics promote IDH1-dependent HIF1α-tenascin C feedback to regulate glioblastoma aggression.
Yekaterina A. Miroshnikova,Janna K. Mouw,J. Matthew Barnes,Michael W. Pickup,Johnathan N. Lakins,Youngmi Kim,Khadjia Lobo,Anders Persson,Gerald F. Reis,Tracy R. McKnight,Eric C. Holland,Joanna J. Phillips,Valerie M. Weaver +12 more
TL;DR: It is found that glioma aggression and patient prognosis correlate with HIF1α levels and the stiffness of a tenascin C (TNC)-enriched ECM, and this work suggests that elevated ECM stiffness can independently foster glioblastomas aggression and contribute to gliOBlastoma recurrence via bypassing the protective activity of IDH1 mutational status.