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Joshua L. Roffman

Researcher at Harvard University

Publications -  126
Citations -  24672

Joshua L. Roffman is an academic researcher from Harvard University. The author has contributed to research in topics: Genome-wide association study & Medicine. The author has an hindex of 43, co-authored 110 publications receiving 19588 citations. Previous affiliations of Joshua L. Roffman include Semel Institute for Neuroscience and Human Behavior & National Institutes of Health.

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Biological insights from 108 schizophrenia-associated genetic loci

Stephan Ripke, +354 more
- 24 Jul 2014 - 
TL;DR: Associations at DRD2 and several genes involved in glutamatergic neurotransmission highlight molecules of known and potential therapeutic relevance to schizophrenia, and are consistent with leading pathophysiological hypotheses.
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The organization of the human cerebral cortex estimated by intrinsic functional connectivity

B.T. Thomas Yeo, +16 more
- 01 Sep 2011 - 
TL;DR: In this paper, the organization of networks in the human cerebrum was explored using resting-state functional connectivity MRI data from 1,000 subjects and a clustering approach was employed to identify and replicate networks of functionally coupled regions across the cerebral cortex.
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Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores

Bjarni J. Vilhjálmsson, +394 more
- 01 Oct 2015 - 
TL;DR: LDpred is introduced, a method that infers the posterior mean effect size of each marker by using a prior on effect sizes and LD information from an external reference panel, and outperforms the approach of pruning followed by thresholding, particularly at large sample sizes.
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Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects

Christian R. Marshall, +329 more
- 01 Jan 2017 - 
TL;DR: In this article, a centralized analysis pipeline was applied to a SCZ cohort of 21,094 cases and 20,227 controls, and a global enrichment of copy number variants (CNVs) was observed in cases (odds ratio (OR) = 1.11, P = 5.7 × 10-15), which persisted after excluding loci implicated in previous studies.
Posted ContentDOI

A contribution of novel CNVs to schizophrenia from a genome-wide study of 41,321 subjects

Christian R. Marshall, +255 more
- 23 Feb 2016 - 
TL;DR: A collaborative effort in which a centralized analysis pipeline is applied to a SCZ cohort, finding support at a suggestive level for nine additional candidate susceptibility and protective loci, which consist predominantly of CNVs mediated by non-allelic homologous recombination (NAHR).