K
Kim C. M. van der Elst
Researcher at University Medical Center Groningen
Publications - 19
Citations - 306
Kim C. M. van der Elst is an academic researcher from University Medical Center Groningen. The author has contributed to research in topics: Medicine & Chemistry. The author has an hindex of 7, co-authored 11 publications receiving 254 citations. Previous affiliations of Kim C. M. van der Elst include University of Groningen.
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Journal ArticleDOI
Therapeutic Drug Monitoring of Posaconazole: an Update
Bart G. J. Dekkers,Martijn Bakker,Kim C. M. van der Elst,Marieke G G Sturkenboom,Anette Veringa,Lambert F.R. Span,Jan-Willem C. Alffenaar +6 more
TL;DR: The most recent findings on pharmacokinetics and pharmacodynamics of posaconazole in the setting of prophylaxis and treatment of fungal infections are highlighted and the challenges associated with TDM are referred to.
Journal ArticleDOI
Dried blood spot analysis suitable for therapeutic drug monitoring of voriconazole, fluconazole, and posaconazole.
Kim C. M. van der Elst,Lambert F.R. Span,Kai van Hateren,Karin M. Vermeulen,Tjip S. van der Werf,Ben Greijdanus,Jos G. W. Kosterink,Jos G. W. Kosterink,Donald R. A. Uges,Jan-Willem C. Alffenaar +9 more
TL;DR: DBS analysis is a reliable alternative to venous blood sampling and can be used for therapeutic drug monitoring of voriconazoles, fluconazole, and posaconazole.
Journal ArticleDOI
Low Caspofungin Exposure in Patients in Intensive Care Units
Kim C. M. van der Elst,Anette Veringa,Jan G. Zijlstra,Albertus Beishuizen,Rob Klont,Petra Brummelhuis-Visser,Donald R. A. Uges,Daan J Touw,Jos G. W. Kosterink,Jos G. W. Kosterink,Tjip S. van der Werf,Jan-Willem C. Alffenaar +11 more
TL;DR: The caspofungin exposure in ICU patients in this study was low compared with that in healthy volunteers and other (non)critically ill patients, most likely due to a larger volume of distribution.
Journal ArticleDOI
Insufficient Fluconazole Exposure in Pediatric Cancer Patients and the Need for Therapeutic Drug Monitoring in Critically Ill Children
Kim C. M. van der Elst,Marieke Pereboom,Edwin R. van den Heuvel,Jos G. W. Kosterink,Elisabeth H. Schölvinck,Jan-Willem C. Alffenaar +5 more
TL;DR: The fluconazole concentration is not sufficient in pediatric cancer patients with the currently recommended dose regimen, and a higher fluconzole dose is required to achieve adequate drug exposure.
Journal ArticleDOI
Subtherapeutic Posaconazole Exposure and Treatment Outcome in Patients With Invasive Fungal Disease
Kim C. M. van der Elst,Charlie H. S. Brouwers,Edwin R. van den Heuvel,Marjolijn J. P. van Wanrooy,Donald R. A. Uges,Tjip S. van der Werf,Jos G. W. Kosterink,Lambert F.R. Span,Jan-Willem C. Alffenaar +8 more
TL;DR: Therapeutic drug monitoring of posaconazole can detect underexposure and can be helpful in treatment optimization and positively correlated with a successful treatment outcome.