Therapeutic Drug Monitoring of Posaconazole: an Update
Bart G. J. Dekkers,Martijn Bakker,Kim C. M. van der Elst,Marieke G G Sturkenboom,Anette Veringa,Lambert F.R. Span,Jan-Willem C. Alffenaar +6 more
TLDR
The most recent findings on pharmacokinetics and pharmacodynamics of posaconazole in the setting of prophylaxis and treatment of fungal infections are highlighted and the challenges associated with TDM are referred to.Abstract:
Posaconazole is a second-generation triazole agent with a potent and broad antifungal activity. In addition to the oral suspension, a delayed-release tablet and intravenous formulation with improved pharmacokinetic properties have been introduced recently. Due to the large interindividual and intraindividual variation in bioavailability and drug-drug interactions, therapeutic drug monitoring (TDM) is advised to ensure adequate exposure and improve clinical response for posaconazole. Here, we highlight and discuss the most recent findings on pharmacokinetics and pharmacodynamics of posaconazole in the setting of prophylaxis and treatment of fungal infections and refer to the challenges associated with TDM of posaconazole.read more
Citations
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Pharmacokinetics of antifungal drugs: practical implications for optimized treatment of patients.
TL;DR: This review summarises published pharmacokinetic data on systemically administered antifungals focusing on co-morbidities, target-site penetration, and combination antIFungal therapy for cryptococcosis and mucormycosis.
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Breakthrough invasive mold infections in the hematology patient: Current concepts and future directions
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Mass spectrometry-based metabolomics in health and medical science: a systematic review
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Candida infections in solid organ transplantation: Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice.
Saima Aslam,Coleman Rotstein +1 more
TL;DR: These updated guidelines from the American Society of Transplantation Infectious Diseases Community of Practice provide recommendations for the diagnosis and management of Candida infections in solid organ transplant recipients.
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Aspergillus fumigatus and aspergillosis: From basics to clinics.
Amir Arastehfar,Agostinho Carvalho,Jos Houbraken,Lisa Lombardi,Rocio Garcia-Rubio,Jeffrey D. Jenks,Olga Rivero-Menendez,R. Aljohani,Ilse D. Jacobsen,J. Berman,N. Osherov,Mohammad Taghi Hedayati,Macit Ilkit,Darius Armstrong-James,Toni Gabaldón,J. Meletiadis,M. Kostrzewa,Weihua Pan,Cornelia Lass-Flörl,David S. Perlin,Martin Hoenigl,Martin Hoenigl +21 more
TL;DR: In this article, the authors comprehensively discuss the current clinical challenges caused by A. fumigatus and provide insights on how to address them and provide a continuous quest for novel antifungal drugs.
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