M
Marc R. J. Carlson
Researcher at Fred Hutchinson Cancer Research Center
Publications - 20
Citations - 9059
Marc R. J. Carlson is an academic researcher from Fred Hutchinson Cancer Research Center. The author has contributed to research in topics: Bioconductor & Regeneration (biology). The author has an hindex of 19, co-authored 20 publications receiving 7458 citations. Previous affiliations of Marc R. J. Carlson include University of California & Seattle Children's Research Institute.
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Journal ArticleDOI
Software for computing and annotating genomic ranges.
Michael F. Lawrence,Wolfgang Huber,Hervé Pagès,Patrick Aboyoun,Marc R. J. Carlson,Robert Gentleman,Martin Morgan,Vincent J. Carey +7 more
TL;DR: This work describes Bioconductor infrastructure for representing and computing on annotated genomic ranges and integrating genomic data with the statistical computing features of R and its extensions, including those for sequence analysis, differential expression analysis and visualization.
Journal ArticleDOI
Orchestrating high-throughput genomic analysis with Bioconductor
Wolfgang Huber,Vincent J. Carey,Robert Gentleman,Simon Anders,Marc R. J. Carlson,Benilton S. Carvalho,Héctor Corrada Bravo,Sean Davis,Laurent Gatto,Thomas Girke,Raphael Gottardo,Florian Hahne,Kasper D. Hansen,Rafael A. Irizarry,Michael S. Lawrence,Michael I. Love,James W. MacDonald,Valerie Obenchain,Andrzej K. Oleś,Hervé Pagès,Alejandro Reyes,Paul Shannon,Gordon K. Smyth,Dan Tenenbaum,Levi Waldron,Martin Morgan +25 more
TL;DR: An overview of Bioconductor, an open-source, open-development software project for the analysis and comprehension of high-throughput data in genomics and molecular biology, which comprises 934 interoperable packages contributed by a large, diverse community of scientists.
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Analysis of oncogenic signaling networks in glioblastoma identifies ASPM as a molecular target
Steve Horvath,Bin Zhang,Marc R. J. Carlson,K. V. Lu,Shaojun Zhu,R. M. Felciano,M. F. Laurance,W. Zhao,S. Qi,Zhihong Chen,Yohan Lee,Adrienne C. Scheck,Linda M. Liau,Hong Wu,Daniel H. Geschwind,Phillip G. Febbo,Harley I. Kornblum,Timothy F. Cloughesy,Stanley F. Nelson,Paul S. Mischel +19 more
TL;DR: The weighted gene coexpression network analysis provides a blueprint for leveraging genomic data to identify key control networks and molecular targets for glioblastoma, and the principle eluted from this work can be applied to other cancers.
Journal ArticleDOI
Regulatory T cell development in the absence of functional Foxp3
Wen Lin,Dipica Haribhai,Lance M. Relland,Nga Truong,Marc R. J. Carlson,Calvin B. Williams,Talal A. Chatila +6 more
TL;DR: The results indicate that Treg cell effector function but not lineage commitment requires the expression of functional Foxp3 protein.
Journal ArticleDOI
New insights into the Tyrolean Iceman's origin and phenotype as inferred by whole-genome sequencing
Andreas Keller,Angela Graefen,Markus Ball,Mark Matzas,Valesca Boisguerin,Frank Maixner,Petra Leidinger,Christina Backes,Rabab Khairat,Michael Forster,Bjoern Stade,Andre Franke,Jens Mayer,Jessica Spangler,Stephen F. McLaughlin,Minita Shah,Clarence Lee,Timothy T. Harkins,Alexander Sartori,Andrés Moreno-Estrada,Brenna M. Henn,Martin Sikora,Ornella Semino,Jacques Chiaroni,Siiri Rootsi,Natalie M. Myres,Vicente M. Cabrera,Peter A. Underhill,Carlos Bustamante,Eduard Egarter Vigl,Marco Samadelli,Giovanna Cipollini,Jan Haas,Hugo A. Katus,Brian O'Connor,Marc R. J. Carlson,Benjamin Meder,Nikolaus Blin,Nikolaus Blin,Eckart Meese,Carsten M. Pusch,Albert Zink +41 more
TL;DR: The complete genome sequence of the Iceman is reported and 100% concordance between the previously reported mitochondrial genome sequence and the consensus sequence generated from the genomic data is shown.