M
Martin Robert
Researcher at Keio University
Publications - 25
Citations - 3219
Martin Robert is an academic researcher from Keio University. The author has contributed to research in topics: Metabolomics & Sperm motility. The author has an hindex of 20, co-authored 25 publications receiving 3003 citations. Previous affiliations of Martin Robert include Nara Institute of Science and Technology & Tohoku University.
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Journal ArticleDOI
Multiple high-throughput analyses monitor the response of E. coli to perturbations.
Nobuyoshi Ishii,Kenji Nakahigashi,Tomoya Baba,Tomoya Baba,Martin Robert,Tomoyoshi Soga,Akio Kanai,Takashi Hirasawa,Miki Naba,Kenta Hirai,Aminul Hoque,Pei Yee Ho,Yuji Kakazu,Kaori Sugawara,Saori Igarashi,Satoshi Harada,Takeshi Masuda,Naoyuki Sugiyama,Takashi Togashi,Miki Hasegawa,Yuki Takai,Katsuyuki Yugi,Kazuharu Arakawa,Nayuta Iwata,Yoshihiro Toya,Yoichi Nakayama,Takaaki Nishioka,Takaaki Nishioka,Kazuyuki Shimizu,Kazuyuki Shimizu,Hirotada Mori,Hirotada Mori,Masaru Tomita +32 more
TL;DR: E. coli seems to use complementary strategies that result in a metabolic network robust against perturbations, and actively regulated enzyme levels to maintain a stable metabolic state in response to changes in growth rate.
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Differential metabolomics reveals ophthalmic acid as an oxidative stress biomarker indicating hepatic glutathione consumption.
Tomoyoshi Soga,Richard Baran,Makoto Suematsu,Yuki Ueno,Satsuki Ikeda,Tadayuki Sakurakawa,Yuji Kakazu,Takamasa Ishikawa,Martin Robert,Takaaki Nishioka,Masaru Tomita +10 more
TL;DR: A metabolome differential display method based on capillary electrophoresis time-of-flight mass spectrometry to profile liver metabolites following acetaminophen-induced hepatotoxicity finds that serum ophthalmate is a sensitive indicator of hepatic GSH depletion, and may be a new biomarker for oxidative stress.
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Bioinformatics Tools for Mass Spectroscopy-Based Metabolomic Data Processing and Analysis.
TL;DR: A state-of-the-art overview of the data processing tools available is provided, with their advantages and disadvantages, and comparisons are made to guide the reader.
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Inactivation of tumor suppressor p53 by mot-2, a hsp70 family member
Renu Wadhwa,Syuichi Takano,Martin Robert,Akiko Yoshida,Hitoshi Nomura,Roger R. Reddel,Youji Mitsui,Sunil C. Kaul +7 more
TL;DR: A novel mechanism of p53 inactivation by mot-2 protein is demonstrated, supported by the down-regulation of p 53-responsive genes p21WAF-1 andmdm-2 in mot-1-transfected cells only and an abrogation of nuclear translocation of wild-type p53.
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Characterization of Prostate-Specific Antigen Proteolytic Activity on its Major Physiological Substrate, the Sperm Motility Inhibitor Precursor/Semenogelin I†
TL;DR: The results suggest that PSA is the main enzyme responsible for the processing of SPMIP/SgI in human semen and that this protease manifests unusual specificity with respect to hydrolyzable substrates and sites of hydrolysis.