P
Padmanee Sharma
Researcher at Mayo Clinic
Publications - 2
Citations - 932
Padmanee Sharma is an academic researcher from Mayo Clinic. The author has contributed to research in topics: CTLA-4 & T cell. The author has an hindex of 2, co-authored 2 publications receiving 685 citations.
Papers
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Journal ArticleDOI
PD-L1 Expression in Triple-Negative Breast Cancer
Elizabeth A. Mittendorf,Anne V. Philips,Funda Meric-Bernstam,Na Qiao,Yun Wu,Susan M. Harrington,Xiaoping Su,Ying Wang,Ana M. Gonzalez-Angulo,Argun Akcakanat,Akhil Chawla,Michael Curran,Patrick Hwu,Padmanee Sharma,Jennifer K. Litton,Jeffrey J. Molldrem,Gheath Alatrash +16 more
TL;DR: Using tissue microarrays containing 105 triple-negative breast cancer specimens, Mittendorf and colleagues show that 20% of the TNBC specimens express PD-L1, half have lost PTEN, and inhibitors of PI3K pathway decrease PD- l1 expression, providing a rationale for therapeutic targeting of PD- L1 for TNBC.
Journal ArticleDOI
Mechanisms of T-cell inhibition: implications for cancer immunotherapy.
TL;DR: This review discusses several regulatory mechanisms that act to control effector T-cell responses and identifies strategies to circumvent these mechanisms in order to improve clinical responses.