Y
Yun Wu
Researcher at University of Texas MD Anderson Cancer Center
Publications - 134
Citations - 10117
Yun Wu is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 43, co-authored 118 publications receiving 7777 citations. Previous affiliations of Yun Wu include University of Texas at Austin & Cerna.
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Journal ArticleDOI
PD-L1 Expression in Triple-Negative Breast Cancer
Elizabeth A. Mittendorf,Anne V. Philips,Funda Meric-Bernstam,Na Qiao,Yun Wu,Susan M. Harrington,Xiaoping Su,Ying Wang,Ana M. Gonzalez-Angulo,Argun Akcakanat,Akhil Chawla,Michael Curran,Patrick Hwu,Padmanee Sharma,Jennifer K. Litton,Jeffrey J. Molldrem,Gheath Alatrash +16 more
TL;DR: Using tissue microarrays containing 105 triple-negative breast cancer specimens, Mittendorf and colleagues show that 20% of the TNBC specimens express PD-L1, half have lost PTEN, and inhibitors of PI3K pathway decrease PD- l1 expression, providing a rationale for therapeutic targeting of PD- L1 for TNBC.
Journal ArticleDOI
Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity
Chia Wei Li,Seung Oe Lim,Weiya Xia,Heng Huan Lee,Li Chuan Chan,Li Chuan Chan,Chu Wei Kuo,Kay-Hooi Khoo,Shih Shin Chang,Jong Ho Cha,Taewan Kim,Jennifer L. Hsu,Jennifer L. Hsu,Jennifer L. Hsu,Yun Wu,Jung Mao Hsu,Hirohito Yamaguchi,Qingqing Ding,Yan Wang,Jun Yao,Cheng Chung Lee,Hsing Ju Wu,Aysegul A. Sahin,James P. Allison,Dihua Yu,Gabriel N. Hortobagyi,Mien Chie Hung +26 more
TL;DR: The results link ubiquitination and glycosylation pathways to the stringent regulation of PD-L1, which could lead to potential therapeutic strategies to enhance cancer immune therapy efficacy.
Journal ArticleDOI
A Genomic Predictor of Response and Survival Following Taxane-Anthracycline Chemotherapy for Invasive Breast Cancer
Christos Hatzis,Lajos Pusztai,Vicente Valero,Daniel J. Booser,Laura J. Esserman,Ana Lluch,Tatiana Vidaurre,Frankie A. Holmes,Eduardo A. Souchon,Hongkun Wang,Miguel Martin,Jose M. Cotrina,Henry L. Gomez,Rebekah Hubbard,J. Ignacio Chacón,Jaime Ferrer-Lozano,Richard Dyer,Meredith Buxton,Yun Gong,Yun Wu,Nuhad K. Ibrahim,Eleni Andreopoulou,Naoto T. Ueno,Kelly K. Hunt,Wei Yang,Arlene Nazario,Angela DeMichele,Joyce O'Shaughnessy,Gabriel N. Hortobagyi,W. Fraser Symmans +29 more
TL;DR: A genomic predictor combining ER status, predicted Chemoresistance, predicted chemosensitivity, and predicted endocrine sensitivity identified patients with high probability of survival following taxane and anthracycline chemotherapy.
Journal ArticleDOI
Deubiquitination and Stabilization of PD-L1 by CSN5
Seung Oe Lim,Chia Wei Li,Weiya Xia,Jong Ho Cha,Li Chuan Chan,Yun Wu,Shih Shin Chang,Shih Shin Chang,Wan Chi Lin,Jung Mao Hsu,Yi Hsin Hsu,Taewan Kim,Wei Chao Chang,Jennifer L. Hsu,Hirohito Yamaguchi,Qingqing Ding,Yan Wang,Yi Yang,Chung-Hsuan Chen,Aysegul A. Sahin,Dihua Yu,Dihua Yu,Gabriel N. Hortobagyi,Mien Chie Hung +23 more
TL;DR: It is demonstrated that COP9 signalosome 5 (CSN5), induced by NF-κB p65, is required for TNF-α-mediated PD-L1 stabilization in cancer cells, and inhibition of CSN5 by curcumin diminished cancer cell PD- L1 expression and sensitized cancer cells to anti-CTLA4 therapy.
Journal ArticleDOI
PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis
Junwei Hou,Rongce Zhao,Rongce Zhao,Rongce Zhao,Weiya Xia,Chiung Wen Chang,Yun You,Jung Mao Hsu,Jung Mao Hsu,Lei Nie,Yeh Chen,Yu Chuan Wang,Chunxiao Liu,Wei Jan Wang,Wei Jan Wang,Yun Wu,Baozhen Ke,Jennifer L. Hsu,Kebin Huang,Kebin Huang,Zu Ye,Yi Yang,Xianghou Xia,Yintao Li,Chia Wei Li,Bin Shao,Bin Shao,John A. Tainer,Mien Chie Hung,Mien Chie Hung,Mien Chie Hung +30 more
TL;DR: Findings identify a non-immune checkpoint function of PD-L1 and provide an unexpected concept that GSDMC/Caspas-8 mediates non-canonical pyroptosis pathway in cancer cells, causing tumor necrosis.