J
Jeffrey J. Molldrem
Researcher at University of Texas MD Anderson Cancer Center
Publications - 188
Citations - 12193
Jeffrey J. Molldrem is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Antigen & Cytotoxic T cell. The author has an hindex of 52, co-authored 174 publications receiving 11244 citations. Previous affiliations of Jeffrey J. Molldrem include University of Texas System & Mayo Clinic.
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Journal ArticleDOI
PD-L1 Expression in Triple-Negative Breast Cancer
Elizabeth A. Mittendorf,Anne V. Philips,Funda Meric-Bernstam,Na Qiao,Yun Wu,Susan M. Harrington,Xiaoping Su,Ying Wang,Ana M. Gonzalez-Angulo,Argun Akcakanat,Akhil Chawla,Michael Curran,Patrick Hwu,Padmanee Sharma,Jennifer K. Litton,Jeffrey J. Molldrem,Gheath Alatrash +16 more
TL;DR: Using tissue microarrays containing 105 triple-negative breast cancer specimens, Mittendorf and colleagues show that 20% of the TNBC specimens express PD-L1, half have lost PTEN, and inhibitors of PI3K pathway decrease PD- l1 expression, providing a rationale for therapeutic targeting of PD- L1 for TNBC.
Journal ArticleDOI
Evidence that specific T lymphocytes may participate in the elimination of chronic myelogenous leukemia
Jeffrey J. Molldrem,Peter P. Lee,Changqing Wang,Kyrie Felio,Hagop M. Kantarjian,Richard E. Champlin,Mark M. Davis +6 more
TL;DR: There was a strong correlation between the presence of PR1-specific T cells and clinical responses after IFN-α and allogeneic BMT, providing for the first time direct evidence of a role for T-cell immunity in clearing malignant cells.
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Melphalan and purine analog–containing preparative regimens: reduced-intensity conditioning for patients with hematologic malignancies undergoing allogeneic progenitor cell transplantation
Sergio Giralt,Peter F. Thall,Issa F. Khouri,Xuemei Wang,Ira Braunschweig,Cindy Ippolitti,David F. Claxton,Michele L. Donato,J. Bruton,A. Cohen,Marilyn S. Davis,Borje S. Andersson,Paolo Anderlini,James Gajewski,Steven M. Kornblau,Michael Andreeff,Donna Przepiorka,Naoto T. Ueno,Jeffrey J. Molldrem,Richard E. Champlin +19 more
TL;DR: Fludarabine/melphalan combinations are feasible in older patients with associated comorbidities, and long-term disease control can be achieved with reduced-intensity conditioning in this population, according to multivariate analysis.
Journal ArticleDOI
Monoculture-derived T lymphocytes specific for multiple viruses expand and produce clinically relevant effects in immunocompromised individuals.
Ann M. Leen,G. Doug Myers,Uluhan Sili,M. Helen Huls,Heidi L. Weiss,Kathryn S. Leung,George Carrum,Robert A. Krance,Chung Che Chang,Jeffrey J. Molldrem,Adrian P. Gee,Malcolm K. Brenner,Helen E. Heslop,Cliona M. Rooney,Catherine M. Bollard +14 more
TL;DR: Genetic modification of antigen-presenting cell lines are described to facilitate the production of CD4+ and CD8+ T lymphocytes specific for CMV, EBV and several serotypes of adenovirus from a single cell culture.
Journal ArticleDOI
Cord-blood engraftment with ex vivo mesenchymal-cell coculture.
Marcos de Lima,Ian McNiece,Simon N. Robinson,Mark F. Munsell,Mary Eapen,Mary M. Horowitz,Amin M. Alousi,Rima M. Saliba,John McMannis,Indreshpal Kaur,Partow Kebriaei,Simrit Parmar,Uday R. Popat,Chitra Hosing,Richard E. Champlin,Catherine M. Bollard,Jeffrey J. Molldrem,Roy B. Jones,Yago Nieto,Borje S. Andersson,Nina Shah,Betul Oran,Laurence J.N. Cooper,Laura L. Worth,Muzaffar H. Qazilbash,Martin Korbling,Gabriela Rondon,Stefan O. Ciurea,Doyle Bosque,I. Maewal,Paul J. Simmons,Elizabeth J. Shpall +31 more
TL;DR: Transplantation of cord-blood cells expanded ex vivo in cocultures with allogeneic mesenchymal stromal cells appeared to be safe and effective and significantly improved engraftment, as compared with unmanipulated cord blood only.