Pernille Keller

TL;DR: It is proposed that IL-6 and other cytokines, which are produced and released by skeletal muscles, exerting their effects in other organs of the body, should be named ‘myokines’.

TL;DR: Combining RNA profiling with single-gene DNA marker association analysis yields a strongly validated molecular predictor with meaningful explanatory power for VO2max responses to endurance training.

TL;DR: It is reported here that incubation with IL-6 increases the phosphorylation of AMPK and that of its target molecule, acetyl CoA carboxylase, in both extensor digitorum longus muscle and cultured F422a adipocytes, and that this contributes to, but does not fully account for, the increase in AMPK activity in these tissues in response to exercise.

TL;DR: It is suggested that muscle-derived IL-6 fulfils the criteria of an exercise factor and that such classes of cytokines could be termed ‘myokines’.

TL;DR: It would appear that miRNAs can produce marked changes in target protein abundance in vivo by working in a combinatorial manner, and miRNA detection represents a new molecular biomarker strategy for insulin resistance, where micrograms of patient material is needed to monitor efficacy during drug or life-style interventions.